Harvesting the power of the cell’s own protein degradation mechanisms in drug discovery
Posted 21st October 2020 by Joshua Sewell
Constant production of proteins in living cells is subject to strict quality and concentration control. The ubiquitin-protease system (UPS) is one of the systems responsible for degrading misfolded and damaged proteins. Also, short-lived regulatory proteins that control many critical cellular processes, including cell cycle progression, cell proliferation and differentiation, cell signalling and transcription are degraded by UPS.1
AI to leverage data and close the loop between patient data and R&D
Posted 15th October 2020 by Nicholas Noakes
Ahead of the Global Pharma R&D AI, Data Science and Informatics Summit we sat down with Claire Biot to talk about her work to provide life science companies & professionals with a scientific and business platform to imagine sustainable innovations, capable of improving patient & physician experience in the age of precision medicine.
Why haven’t microbial products been more widely adopted by farmers?
Posted 14th October 2020 by Joshua Sewell
This is a question that drives me each day. Microbial products have been around for a long time; starting with rhizobium in legumes, dating back 125 years. Yet, in the United States, rhizobium inoculants have not been widely adopted by soybean farmers – some indicate less than 15% use overall in the United States. Why?
Deep Neural Networks in image processing, predictive modelling and diagnostic decisions
Posted 2nd September 2020 by Liv Sewell
Now more than ever intelligent human beings are needed to fulfil high value and high complexity tasks and histopathology is no exception. In fact, it is one of the sectors in the most desperate need.
Multiplex and high fidelity: the potential of qPCR
Posted 28th August 2020 by Joshua Sewell
Ahead of the qPCR & Digital PCR Congress, we sat down with David Zhang to talk about his work with PCR as a diagnostic platform.
From Consortia to Recombinants: opportunities and challenges facing the next generation of microbials
Posted 24th August 2020 by Liv Sewell
In this blog post I will discuss two themes that I see driving the next generation of live microbe biologicals for agriculture. These are the rational design and delivery of pairs or consortia (which I will define as more than two microbes) and the commercialization of engineered strains.
How deep learning is transforming medical imaging: image search
Posted 29th July 2020 by Liv Sewell
Five or six years ago, I was looking for a strategic direction for the KIMIA Lab. We started with the problems. We asked, ‘What problems do we have in medical imaging?’
Colorectal cancer discovery raises hope for microbiome treatment
Posted 22nd July 2020 by Joshua Sewell
This article is republished with kind permission from BioVox.
A new mechanism causing colorectal cancer has been discovered by researchers from VIB and Ghent University.
