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Exploring the gut-brain axis in neurodevelopmental disorders

In the last decade, research has well established (relatively speaking) the impact of gut microbiota on host physiology and behaviour. We know that the gut and the brain communicate bidirectionally. The gut-brain axis includes nerval, endocrine and immunologic pathways. What is less well established is whether alterations in gut microbial composition can affect brain structure and function in neurodevelopmental disorders.

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Augustine Therapeutics: Bridging the Valley of Death with VIB Discovery Sciences

This article is republished with kind permission from BioVox.

Augustine Therapeutics is one of VIB’s latest spinoffs, developing a first-in-class drug for Charcot-Marie-Tooth disease. The company recently announced a seed-funding round of €4.2 million, led by V-Bio Ventures. We spoke to several of the key persons in Augustine about how the startup is tackling the “Valley of Death”: the no-man’s-land between academia and industry where many potential therapies often fail.

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Digital Pathology, Computational Biology, Organ Transplants, & the Future of Medicine

Both transplant outcomes and lab methods have stagnated over the last 40 years. Ishita Moghe and Professor Kim Solez comment upon the rapidly changing landscape of medical research and the potential of digital pathology for transforming patient outcomes.

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The grass has never been greener for engineering plant immunity and resilience

Scientific research is always working at the frontiers of knowledge, but plant genomics technologies have had a dramatic impact on plant science even by our standards. The wide availability of sequencing technologies has been a rare step-change that has unlocked knowledge in a way nobody in the field could have imagined twenty years ago. Knowledge which could make a considerable contribution to food security in the face of changing climates.

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Developing computationally derived imaging biomarkers for maximum clinical impact

Professor Anant Madabhushi is a world-recognised, award-winning leader in computerized imaging research and translational applications, with over 160 peer-reviewed journal publications and close to 100 patents issued or pending. He is a keynote speaker at the 6th Digital Pathology & AI Congress: USA. He explains here why having patents is not enough…

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New Breeding Techniques: cloning major resistance genes in cereals

Advances in breeding techniques for cereal crops will be a focus at the 8th Plant Genomics and Gene Editing Congress: USA. We asked Burleigh Dodds, an agricultural science publisher, to share an extract from one of their recent publications, ‘Advances in breeding techniques for cereal crops’.

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Culturing the uncultured: isolating human microbial ‘dark matter’

A large fraction of the microorganisms that constitute the human microbiome have remained uncultured. Some of the uncultured microbes have close relatives that have been cultured. However, there are also whole groups of microbes that don’t have relatives in culture.

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Developing Deep Learning Models for Pathology Analysis

Ahead of the 6th Digital Pathology & AI Congress: USA, Dr Saeed Hassanpour introduces us to the subject of his presentation: the opportunities and challenges in developing deep learning based tools for histology.

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