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  • A regulatory roadmap for the commercialization of microbial products for agriculture

    A major paradigm shift in agricultural production is required to meet the demands of a global world population projected to reach 9.7 billion in 2050.

  • Falling Off The Cliff: Are We Short Of Pathologists?

    Are we really short of pathologists or close to it?

  • New sourcing of natural ingredients for cosmeceuticals

    The sourcing of natural plant-based compounds is becoming a worldwide bottleneck. The Greenhouse Pharmacy programme of Wageningen University & Research builds new chains between high-tech horticulture and cosmeceutical companies for reliable sourcing of pesticide-free natural plant compounds.

  • Will the intersection of blockchain and AI inspire the Pharma R&D Renaissance?

    One of its great strengths of blockchain is its great weakness: the fact that the ledger is immutable.

Presentation Slides from the 4th Partnerships in Biocontrol, Biostimulants & Microbiome Congress: USA

At the recent 4th Partnerships in Biocontrol, Biostimulants & Microbiome Congress: USA we heard a number of interesting presentations on how plant and soil microbiome research is identifying microbes to enhance crop productivity and disease resistance.

Thanks to some of our speakers, we have made the following slides discussing the current regulatory landscape from Sarah Caffery, Keith Matthews, and Terry Stone available to view.

Read More

The Future is Bright for Probiotics

I am extremely sceptical of all claims about probiotics. For the last 10 years of running Probiotics.org, companies have been sending me questionable products with extraordinarily impossible to believe claims.

But, after Global Engage’s 4th Probiotic & Prebiotics Congress, here’s what I strongly believe:

Read More

Presentation Slides from the 7th Plant Genomics & Gene Editing Congress: USA

The recent 7th Plant Genomics Congress: USA provided a fantastic opportunity to discover how novel gene-editing technologies, CRISPR and other ‘omics’ technologies are being applied to research and product development. We have made the following slides from Jerry Feitelson, Lynne Reuber, Greg Bryan and Chloe Pavely available to view.

Read More

3 Ways Single-Cell Sequencing and AI are Transforming Kidney Transplantation

Transplantation is now a successful therapy for end-stage renal disease (ESRD). The first successful kidney transplantation happened in Boston in 1954 and the procedure is now routine clinical practice in more than 80 countries worldwide.

Ishita Moghe and Kim Solez outline some of the major strides taken in kidney pathology and transplantation through the use of scRNA-seq and Artificial Intelligence (AI). 

Read More

Slides from the 4th Medicinal Chemistry & Protein Degradation Summit

The 4th Medicinal Chemistry & Protein Degradation Summit provided two days of fascinating topics and case studies about AI-assisted lead optimisation, DNA encoded libraries and the use of data and informatics in drug-discovery. We have made the following presentation slides available from Greg Makara, Paul Colbon and Yugal Sharma.

Read More

Even with genetic modification, resistance may be a nasty problem

Natural resistance to our methods to control pests and weeds is a brand new phenomenon, historically speaking. It only evolved as mankind started to use chemical, and later biotechnological means to control nature. Genetic modification may not be the answer to resistance. Attempts to control pests and weeds by growing GM plants run into the same problem as the application of chemical agents. But still, nature may provide some answers.

Read More

Digital Pathology Solutions for low-budget and low-tech regions of the world

Digital pathology is transforming possibilities for patient care and the nature of pathologists’ work. But it is clear that in low-income countries, access to pathology and laboratory medicine (PALM) services is very restricted and under-developed.[1] Low-income countries bear a disproportionate share of the global disease burden, yet they are so under-resourced in the pathology and laboratory services that are vital for the accurate diagnosis and treatment of disease.[2] This presents a huge issue for global health.

Given this global context, Rebecca Calder, Daniel Stevens and Zev Leifer’s poster, presented at the 5th Digital Pathology and AI Congress, is of notable significance.

Read More

Diverse Approaches in Immuno-Oncology: A Review of the Research & Technology Series

This blog was published on Clarivate’s Cortellis blog. It is reproduced here with their kind permission.

A fascinating range of insights into the ways in which the immune system can be harnessed to fight cancer was provided by Global Engage’s Immuno-Oncology Research & Technology Series meeting held in October in London. The conference comprised five concurrent tracks covering cutting-edge developments in fields such as cell therapies, novel antibodies and neoantigens. Some of the highlights tracked by the Cortellis team are presented below.

Read More

The Future is Bright for Probiotics

I am extremely sceptical of all claims about probiotics. For the last 10 years of running Probiotics.org, companies have been sending me questionable products with extraordinarily impossible to believe claims.

But, after Global Engage’s 4th Probiotic & Prebiotics Congress, here’s what I strongly believe:

Read More

3 Ways Single-Cell Sequencing and AI are Transforming Kidney Transplantation

Transplantation is now a successful therapy for end-stage renal disease (ESRD). The first successful kidney transplantation happened in Boston in 1954 and the procedure is now routine clinical practice in more than 80 countries worldwide.

Ishita Moghe and Kim Solez outline some of the major strides taken in kidney pathology and transplantation through the use of scRNA-seq and Artificial Intelligence (AI). 

Read More

Slides from the 4th Medicinal Chemistry & Protein Degradation Summit

The 4th Medicinal Chemistry & Protein Degradation Summit provided two days of fascinating topics and case studies about AI-assisted lead optimisation, DNA encoded libraries and the use of data and informatics in drug-discovery. We have made the following presentation slides available from Greg Makara, Paul Colbon and Yugal Sharma.

Read More

Digital Pathology Solutions for low-budget and low-tech regions of the world

Digital pathology is transforming possibilities for patient care and the nature of pathologists’ work. But it is clear that in low-income countries, access to pathology and laboratory medicine (PALM) services is very restricted and under-developed.[1] Low-income countries bear a disproportionate share of the global disease burden, yet they are so under-resourced in the pathology and laboratory services that are vital for the accurate diagnosis and treatment of disease.[2] This presents a huge issue for global health.

Given this global context, Rebecca Calder, Daniel Stevens and Zev Leifer’s poster, presented at the 5th Digital Pathology and AI Congress, is of notable significance.

Read More

Diverse Approaches in Immuno-Oncology: A Review of the Research & Technology Series

This blog was published on Clarivate’s Cortellis blog. It is reproduced here with their kind permission.

A fascinating range of insights into the ways in which the immune system can be harnessed to fight cancer was provided by Global Engage’s Immuno-Oncology Research & Technology Series meeting held in October in London. The conference comprised five concurrent tracks covering cutting-edge developments in fields such as cell therapies, novel antibodies and neoantigens. Some of the highlights tracked by the Cortellis team are presented below.

Read More

Deep Learning based detection of tumor tissue compartments improves prognostic immunoprofiling in muscle-invasive bladder cancer

Worldwide, bladder cancer (BC) is the 11th most commonly diagnosed cancer. In men, BC is the 7thmost commonly diagnosed cancer worldwide.[1]Although men are more likely to develop BC than women, women present with more advanced disease and have worse survival rates.[2]

Muscle-invasive bladder cancers (MIBC) are cancers that have grown into or through the muscle layers of the bladder wall.

Dr. Katharina Nekolla and Ansh Kapil and their team applied Deep Learning enabled pathology to better understand prognostic factors in MIBC. Here we review the significance of the research and share their original poster.

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5 Ways Sleep And Microbiome Are Interrelated With Immunity And Cognition

The effect of sleep on the microbiome of the host has been a topic of interest among researchers for the past several years. Studies have yielded opposing results in how short sleep affects the microbiome. While some showed a significant change in Firmicutes to Bacteroidetes ratio, others found no microbial change following short-term sleep restriction.

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How will Ground Truth Colour Standardisation yield the benefits of AI in Medical Imaging?

The essence of colour management is to ensure that the original target translates through a digital pathway so that the output images are exactly the same colour as the original.

When applied to medical imaging, and considering all the specific stains used in pathology, colour management becomes important. Particular coloured stains bind specific structures of cells in tissue to confer visualisation of diagnostic information. Without translating the colour through the digital pathway correctly, you lose the aspect of diagnostic information, which comes from specific colours.

Read More

Presentation Slides from the 4th Partnerships in Biocontrol, Biostimulants & Microbiome Congress: USA

At the recent 4th Partnerships in Biocontrol, Biostimulants & Microbiome Congress: USA we heard a number of interesting presentations on how plant and soil microbiome research is identifying microbes to enhance crop productivity and disease resistance.

Thanks to some of our speakers, we have made the following slides discussing the current regulatory landscape from Sarah Caffery, Keith Matthews, and Terry Stone available to view.

Read More

Presentation Slides from the 7th Plant Genomics & Gene Editing Congress: USA

The recent 7th Plant Genomics Congress: USA provided a fantastic opportunity to discover how novel gene-editing technologies, CRISPR and other ‘omics’ technologies are being applied to research and product development. We have made the following slides from Jerry Feitelson, Lynne Reuber, Greg Bryan and Chloe Pavely available to view.

Read More

Even with genetic modification, resistance may be a nasty problem

Natural resistance to our methods to control pests and weeds is a brand new phenomenon, historically speaking. It only evolved as mankind started to use chemical, and later biotechnological means to control nature. Genetic modification may not be the answer to resistance. Attempts to control pests and weeds by growing GM plants run into the same problem as the application of chemical agents. But still, nature may provide some answers.

Read More

A regulatory roadmap for the commercialization of microbial products for agriculture

A major paradigm shift in agricultural production is required to meet the demands of a global world population projected to reach 9.7 billion in 2050. We have to increase crop productivity sustainably while preserving biodiversity, natural resources, and grower income in the context of climate change. To optimize sustainable productivity and profitability on farms, grasslands, and forests, scientists and growers must embrace a holistic, systems-level approach and focus on the complexity within phytobiomes.

Read More

Slides from the Plant Genomics & Gene Editing Congress: Europe

The latest event in the Plant Genomics series provided two days of intriguing topics and case studies, not least concerning the ECJ ruling on gene editing and Machine Learning techniques in plant genomics. We have made the following presentation slides available from Ian Bancroft, Anna Coll, Aalt-Jan van Dijk, Nigel Halford, and Jurriaan Ton.

Read More

Microbial solutions to improve crop growth, crop protection, and crop yield

Gregory Maloney, Senior Scientist at Novozymes BioAg will be hosting a roundtable discussion at the Partnerships in Biocontrol, Biostimulants & Microbiome Congress: USA on navigating the regulatory landscape of biological product development. We spoke to him ahead of the congress about his work.

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A new kind of pheromone to control agricultural pests

Karl Cameron Schiller is co-founder of Pheronym, a Davis-based agriculture biotech start-up using a new kind of pheromone from microscopic roundworms called nematodes to control agricultural pests. We asked him about his work.

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Navigating the regulatory landscape for agricultural products

Terry Stone has worked in agricultural products for almost 30 years and has experience in both research and regulatory affairs. He is currently President, TB Stone Solutions. He was previously Vice President of Regulatory Affairs and Sustainability Programs for Agrinos, where he worked with industry associations in the US and the EU to develop a regulatory framework for plant biostimulants. We spoke to him about his work.

Read More

Examining Blockchain Systems & Designing Smart Contracts

The blockchain has the potential to enable the collaboration between patients, researchers, and care providers to provide individualised care for patients, but how can this technology be harnessed in a practical way?

This was one of the key questions that was asked at the Blockchain in Healthcare Congress and we had the pleasure of welcoming an array of expert speakers from pharma, academia, and industry to provide the answer.

Read More

The role of extrinsic motivation in sports and physical activity

Motivation is one of the most significant psychological concepts in many areas of life – from work and education to achieving personal goals. In sports and physical activity, motivation plays an especially important part due to the fact that, to millions of people worldwide, staying fit and active is not an obligation or a professional prerequisite, but rather a personal goal. Blockchain technology, together with elements of gamification, may actually help people achieve this goal.

Read More

Conciliating Blockchain and GDPR

Aurélie Bayle is a Data Protection Officer at be-ys: a role she considers to be at the heart of the new legal framework for any company.

Before GDPR came into effect on 25th May 2018, she was working towards global compliance, which involved completing all the steps given by the Article 29 Data Protection Working Party, an advisory board made up of a representative from the data authority of each EU Member State, the European Data Protection Supervisor, and the European Commission. Her duties have included auditing the structures and processes, preparing the data protection impact assessments, checking the compliance of processing activities, analysing the risks of the processing in the medical area, preparing new processes and policies about data protection, and asking data processors about their own compliance.

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When Blockchain Meets the Right to be Forgotten: Technology Versus Law

Over the past few years, the popularity of the blockchain and cryptocurrencies has increased and has reached important notoriety, not only in scientific and IT journals, but also in the media. Although there are many kinds of cryptocurrencies in circulation nowadays, the most popular is Bitcoin.

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Supporting Blockchain Startups: An Open Letter from Katherine Merton

Dear colleagues,

The blockchain technology market is expected to grow to 2.3 billion US dollars by 2021, from 339.5 million US dollars in 2017. [1] With an annual growth rate of 61.5%, it is one of the fastest growing technologies in the healthcare industry.

Read More

The Big List of Microfluidics Companies & Investors

The microfluidic-based devices market has been growing since 2014 due to the increasing point of care testing demand and the miniaturisation of microfluidic chips. 

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What will we do with all this data?

The amount of data we are creating every day has increased exponentially to match the rise in use of smart and connected devices. The internet of things has connected every aspect of our lives to the digital realm: most of these devices operate by tracking your habits, movements, preferences, voice, and more, then logging those habits online. Specifically, the collection of health data has become abundant, because most people now have or wear some sort of device to track daily patterns, steps, cycles, and more. Even our phones often default to track these things for us, whether we choose to enable the function or not.

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How Standards & Standardised Infrastructure Fuel Innovation

It might surprise a lot of people to learn that standards can be viewed as a tool to support innovation, to set businesses free and to focus on the core of their product where their expertise lie. When working with the use of electronic communication systems within the entire healthcare sector, the main focal point is often ensuring a good support for collaboration and work processes.

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