Posted 22nd March 2019 by Joshua Broomfield
As laboratories transform their workflows into the digital environment, a tremendous opportunity presents itself: to transition the field of pathology from a qualitative to quantitative discipline. Quantitation brings measures of accuracy, reproducibility, and statistical stringency that allow computational algorithms (including AI) to perform complex tasks and measure their success. The evolution of Pathology will not be dictated by any single organization but rather will take an entire community of experts.
Posted 20th March 2019 by Joshua Broomfield
The Human Genome Project was the largest collaborative scientific project that is credited with transforming our understanding of human genetics and revolutionizing medical research. It’s completion in 2003 was greeted as a watershed moment in the history of scientific discovery.
Today, a much less heralded collaborative scientific project is underway that may have implications for human health that could be as profound as that of the Human Genome Project. The Human Microbiome Project (HMP) is a National Institutes of Health (NIH)-supported collaboration that develops “research resources to enable the study of the microbial communities that live in and on our bodies and the roles they play in human health and disease”.
Posted 15th March 2019 by Joshua Broomfield
For over a decade, Memorial Sloan Kettering has implemented digital pathology enterprise system for clinical scanning. Over the years that has evolved significantly. Currently, a lot of our efforts are spent on archive scanning to be available for prospective clinical cases.
Efforts to enable pathologists the ability for primary diagnosis are being explored, and we’re currently validating available systems. There’s always a certain flux in terms of vendor communication and networking, meaning that we’re validating systems for our internal use whether that’s for clinical, education, or research.
Posted 13th March 2019 by Joshua Broomfield
The BioMillenia technology platform is based on microfluidics, a technology platform widely used in life sciences, but not necessarily in microbiology. There are some commercial developments of the technology, for example NGS or dPCR platforms, but it’s a very new application in the field of microbiology.
Posted 8th March 2019 by Joshua Broomfield
The cascade of new discoveries relating health and disease to our gut microbiome has spurred the notion that we now find ourselves in the middle of a “microbiome revolution”. Just to mention some recent examples, mechanisms have been demonstrated for gut bacteria contributing to Parkinson’s disease, determining response to immune checkpoint inhibitor cancer therapy, and even autistic behavior when fecal material from autistic children was transplanted into mice.
Posted 4th March 2019 by Joshua Broomfield
Application of blockchain is no longer a concept known only to a few industries. What started with cryptocurrency in 2009 has come a long way since. Its capability for secure transactions has enabled it to find potential in industries such as banking where security is one of key concerns when it comes to digital transformation. Healthcare industry leaders are also waking up to this call and are now exploring ways to embrace the technology owing to the multiple possible use cases for the industry.
Posted 1st March 2019 by Joshua Broomfield
This is the second of a two-part blog post. In his first post, Liron wrote on embedding AI in Digital Pathology workflows.
Digital Pathology AI apps are certainly feasible, but exactly when they will be ready for clinical use is less clear.
There are potentially hundreds or thousands of algorithms that will need to be developed. Currently, there are only a handful of algorithms that are approved by regulatory bodies for clinical practice, so we’ve got a long way to go.
Posted 27th February 2019 by Joshua Broomfield
Professor Margaret Morris is Chair and Head of Pharmacology, School of Medical Sciences, University of NSW. Her research explores the underlying brain mechanisms in epilepsy, obesity, diabetes, and the link between obesity and high blood pressure. We recently asked her about her research into obesity and the microbiome.