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  • Disease, Ageing and Lifestyle: Considerations from the Microbiome Forum

    Duc H. Le, the UK Editor-in-Chief of EBioMedicine, summarises some of the presentations that took place at the 3rd Microbiome R&D and Business Collaboration Forum: Europe.

  • Printed and Flexible Electronics: An Open Letter From Ton van Mol

    Here at the Holst Centre, our technologies have matured in the last few years and our focus has expanded. We concentrate on application driven research, such as wearable health, automotive, the Internet of Things and solar energy.

  • Plant Science and Agri-Genomics: The Importance of Collaboration

    I love the saying, ‘if you want to go fast, go alone. If you want to go far, go together.’ This is so true in science and research. It takes diverse backgrounds and collaboration to deliver the best products.

  • From Liquid Crystal Displays in 1996 to Microfluidics in 2016

    Emmanuel Delamarche is a researcher at IBM Research who presented at our 2nd Microfluidics Congress about his research on precision diagnostics based on modular capillary-driven elements.

  • ADCs Design and Optimisation

    My research activity focuses on the exploration of new drug delivery technology (categorised into polymer complex/conjugates, nanomedicine, and various types of drug delivery formulations) and the application of validated drug delivery technology to NCE candidates in early/exploratory research stages.

Human Microbiomes Viewed Across Geography

Chronic illnesses such as IBD, obesity and diabetes were once considered ‘western’ diseases. However, changes to diet and lifestyle are steadily taking their toll and prevalence rates are rising across the globe. (1) 

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The pivotal role of assays in biologic and biosimilar discovery and development

The quality, accuracy and reliability of assays is particularly critical when developing biologics and biosimilars. Assays for biologics are more complicated than for small molecules, often relying on assays which provide relative measures in contrast to the more absolute measurements gained from standard crystallisation or purity profiles.

Read More

New Developments in Liquid Biopsy Technology

Advances in liquid biopsy technology have seen the development of novel methods that allow for different applications in genetic disorders and tumour detection.

Read More

Microbiome: Evolution and Revolution

Life started with unicellular microorganisms

They weren’t complex but they reproduced fast – adapting to the catastrophic events (underwater volcanic activity, change in temperature and chemical composition) of their environment in the oceans of the primordial Earth.

Read More

E-waste Recycling and Repurposing

Electronic waste (e-waste) is a fast growing problem. The UN estimates between 20-50 million tons of electronic waste is discarded every year, with only 12.5% of this being recycled. This leaves a colossal amount of e-waste sitting in landfill or improperly disposed of, which in turn leads to toxic materials leaching into the soil and water supply.

Read More

Susceptibility to Alcohol Induced Liver Injury: Driven by Gut Microbiota?

Over the past decade, the intestinal microbiota has increasingly been recognised as a critical factor in health and disease. My research focuses on the role of the gut microbiome in metabolic diseases and my main aim is to prove causality. Most studies describe the gut microbiota from patients and compare it to healthy controls.

Read More

Genomics – Where to Next?

Since January 2008, the cost of sequencing a human genome has outpaced Moore’s Law, which states that computing power doubles every two years. It now costs less than $1000 USD to sequence a human genome to a coverage of 30x.

Read More

Printed and Flexible Electronics: An Open Letter From Ton van Mol

Here at the Holst Centre, our technologies have matured in the last few years and our focus has expanded. We concentrate on application driven research, such as wearable health, automotive, the Internet of Things and solar energy.

Read More

Human Microbiomes Viewed Across Geography

Chronic illnesses such as IBD, obesity and diabetes were once considered ‘western’ diseases. However, changes to diet and lifestyle are steadily taking their toll and prevalence rates are rising across the globe. (1) 

Read More

The pivotal role of assays in biologic and biosimilar discovery and development

The quality, accuracy and reliability of assays is particularly critical when developing biologics and biosimilars. Assays for biologics are more complicated than for small molecules, often relying on assays which provide relative measures in contrast to the more absolute measurements gained from standard crystallisation or purity profiles.

Read More

New Developments in Liquid Biopsy Technology

Advances in liquid biopsy technology have seen the development of novel methods that allow for different applications in genetic disorders and tumour detection.

Read More

Microbiome: Evolution and Revolution

Life started with unicellular microorganisms

They weren’t complex but they reproduced fast – adapting to the catastrophic events (underwater volcanic activity, change in temperature and chemical composition) of their environment in the oceans of the primordial Earth.

Read More

Susceptibility to Alcohol Induced Liver Injury: Driven by Gut Microbiota?

Over the past decade, the intestinal microbiota has increasingly been recognised as a critical factor in health and disease. My research focuses on the role of the gut microbiome in metabolic diseases and my main aim is to prove causality. Most studies describe the gut microbiota from patients and compare it to healthy controls.

Read More

Skin Commensals and T cells: How Do We Keep the Peace?

Tiffany Scharschmidt spoke to us about her thoughts on the skin microbiome, immune responses and inflammatory skin diseases.

Read More

From Liquid Crystal Displays in 1996 to Microfluidics in 2016

Emmanuel Delamarche is a researcher at IBM Research who presented at our 2nd Microfluidics Congress about his research on precision diagnostics based on modular capillary-driven elements.

Read More

ADCs Design and Optimisation

My research activity focuses on the exploration of new drug delivery technology (categorised into polymer complex/conjugates, nanomedicine, and various types of drug delivery formulations) and the application of validated drug delivery technology to NCE candidates in early/exploratory research stages.

Read More

Genomics – Where to Next?

Since January 2008, the cost of sequencing a human genome has outpaced Moore’s Law, which states that computing power doubles every two years. It now costs less than $1000 USD to sequence a human genome to a coverage of 30x.

Read More

Plant Science and Agri-Genomics: The Importance of Collaboration

I love the saying, ‘if you want to go fast, go alone. If you want to go far, go together.’ This is so true in science and research. It takes diverse backgrounds and collaboration to deliver the best products. I find that complex answers are always found in diverse perspectives and collaborations.

Read More

An Interview with Jane Fife: Promoting Plant Growth and Controlling Disease

Jane Fife has nearly 20 years of expertise in application technology and agricultural biologics. Joining  3Bar Biologics in 2016 as Chief Science Officer, her responsibilities include new product development and leading 3Bar’s long-term R&D portfolio.

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Developing Large-Scale Resources for Plant Functional Genomics

Ronan O’Malley has been working to develop large-scale mutant screening collections to identify causal genes within GWAS loci. His final goal is to integrate cistrome, epicistrome, genetic, and natural variant information to understand and ultimately predict how genome and epigenome sequence determines phenotypic outcomes. He spoke to us about his thoughts on plant genomics, bioinformatics and building large-scale resources for functional genomics.

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Working with PCR in agricultural research

Jean B. Ristaino has spent her career studying Phytophthora diseases of global importance, and has recently been awarded with the Excellence in International Service Award by the American Phytopathological Society for her achievements.

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Agricultural Science: Reaching Out to the Curious Consumer

The public overwhelmingly trusts farmers and scientists; they just don’t trust farming or science. This seemingly paradoxical statement stems from an appreciation of the raw potential and critical roles of the professions, but a mistrust of the products they generate.

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Exploring the microbiome in the agricultural industry

‘Microbiome’ has become somewhat of a buzzword within science. There have always been ‘live and active cultures’ in your yogurt, then they were in your dog food and recently doctors started to prescribe probiotics to improve human health and cure some diseases. Now they are helping plants.

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Microbes: a tiny but powerful tool

Crop yield gains over the last century largely resulted from advancements in biotechnology, coupled with extensive use of chemical fertilizers and pesticides. But what if we could increase crop yields while reducing our dependence on chemical fertilizers and pesticides?

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E-waste Recycling and Repurposing

Electronic waste (e-waste) is a fast growing problem. The UN estimates between 20-50 million tons of electronic waste is discarded every year, with only 12.5% of this being recycled. This leaves a colossal amount of e-waste sitting in landfill or improperly disposed of, which in turn leads to toxic materials leaching into the soil and water supply.

Read More

Printed and Flexible Electronics: An Open Letter From Ton van Mol

Here at the Holst Centre, our technologies have matured in the last few years and our focus has expanded. We concentrate on application driven research, such as wearable health, automotive, the Internet of Things and solar energy.

Read More

From Liquid Crystal Displays in 1996 to Microfluidics in 2016

Emmanuel Delamarche is a researcher at IBM Research who presented at our 2nd Microfluidics Congress about his research on precision diagnostics based on modular capillary-driven elements.

Read More

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