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  • The Oral Microbiome is Critical in Understanding Health and Disease

    New understanding of the microbiome is changing ideas about health and is pertinent to our thinking about the role of the oral microbiome in systemic disease.

  • Not Another IT System: Communities of Practice in Pharma

    Ever thought about how you avoid introducing “just another IT system”? How to get to the point where people work with the system joyfully and don’t mutter about the small faults?

  • Quantitative Image Analysis Guidelines

    An open letter from Liron Pantanowitz, Professor of Pathology and Biomedical Informatics at the University of Pittsburgh, USA.

  • Understanding the Molecular Basis of Disease Resistance in Plants

    There has been tremendous progress in understanding the molecular basis of disease resistance in plants in the last twenty years.

  • Synthetic Biology Research and Applications

    An open letter from John Glass, Professor and Leader of the Synthetic Biology and Bioenergy Group at the J. Craig Venter Institute.

Hacking Metabolism to Treat NAFLD

Multifactorial diseases require a safe, multifunctional and integrated approach to treatment. Based on this recognition, a new class of therapeutics, called Defined Amino Acid Compositions (DAACs™), are being pioneered by Axcella Health.

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Seeking Elusive Microbiome Standards

“The two reports chart the ecological landscape of microbiome methods ‘in the wild’ and should engender a newfound sense of urgency to optimize methods and to improve reproducibility between laboratories.”

Read More

What’s New With Prebiotics?

A prebiotic is defined as “a substrate that is selectively utilised by host microorganisms conferring a health benefit”. This updated consensus definition from the International Scientific Association for Probiotics and Prebiotics expands the application outside the digestive tract.

Read More

The Best of Digital Pathology in 2017

It is that time of the year to celebrate the most significant breakthroughs and accomplishments in the field of digital pathology. 2017 has been an exciting year with Philips receiving FDA approval to market their IntelliSite Pathology Solution for primary diagnostic use in the US. 

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A Vision for the Second Green Revolution

There is a Second Green Revolution underway that is harnessing precision agriculture, no-till farming practices, biological, rather than chemical crop inputs and other new, innovative tools that improve soil health and water quality.

Read More

The Case and Need for a Digital Health Ecosystem

The current healthcare climate is on the brink of a long overdue makeover. The clinical research industry has been increasingly plagued by a resistance to change and is subsequently feeling the pain of this reluctance to modify its approach. Indicative of this trend are the rising prices of drug and medical device development, declining patient retention and adherence in clinical research, mounting administrative burdens, and exponentially growing expenses for clinical research that are unsustainable.

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Reproducibility in Computational Biology

Recently Baker and Lithgow (Baker, 2016; Lithgow, et al., 2017) highlighted the problem of the reproducibility in research. Reproducibility criticality affects to different extent a large portion of the science fields (Baker, 2016). Bioinformatics is becoming a key element of many biological/medical studies (Searls, 2010) and reproducibility is also an important issue in this field (Kanwal, et al., 2017; Sandve, et al., 2013).

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George Whitesides on what’s next for Microfluidics – Free Presentation

We were delighted to welcome Professor George Whitesides to the 2nd Microfluidics Congress: USA. If you weren’t able to make it, you can watch his presentation in full here

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Hacking Metabolism to Treat NAFLD

Multifactorial diseases require a safe, multifunctional and integrated approach to treatment. Based on this recognition, a new class of therapeutics, called Defined Amino Acid Compositions (DAACs™), are being pioneered by Axcella Health.

Read More

Seeking Elusive Microbiome Standards

“The two reports chart the ecological landscape of microbiome methods ‘in the wild’ and should engender a newfound sense of urgency to optimize methods and to improve reproducibility between laboratories.”

Read More

What’s New With Prebiotics?

A prebiotic is defined as “a substrate that is selectively utilised by host microorganisms conferring a health benefit”. This updated consensus definition from the International Scientific Association for Probiotics and Prebiotics expands the application outside the digestive tract.

Read More

The Best of Digital Pathology in 2017

It is that time of the year to celebrate the most significant breakthroughs and accomplishments in the field of digital pathology. 2017 has been an exciting year with Philips receiving FDA approval to market their IntelliSite Pathology Solution for primary diagnostic use in the US. 

Read More

The Case and Need for a Digital Health Ecosystem

The current healthcare climate is on the brink of a long overdue makeover. The clinical research industry has been increasingly plagued by a resistance to change and is subsequently feeling the pain of this reluctance to modify its approach. Indicative of this trend are the rising prices of drug and medical device development, declining patient retention and adherence in clinical research, mounting administrative burdens, and exponentially growing expenses for clinical research that are unsustainable.

Read More

Reproducibility in Computational Biology

Recently Baker and Lithgow (Baker, 2016; Lithgow, et al., 2017) highlighted the problem of the reproducibility in research. Reproducibility criticality affects to different extent a large portion of the science fields (Baker, 2016). Bioinformatics is becoming a key element of many biological/medical studies (Searls, 2010) and reproducibility is also an important issue in this field (Kanwal, et al., 2017; Sandve, et al., 2013).

Read More

George Whitesides on what’s next for Microfluidics – Free Presentation

We were delighted to welcome Professor George Whitesides to the 2nd Microfluidics Congress: USA. If you weren’t able to make it, you can watch his presentation in full here

Read More

The Future of Prebiotics

There has been much recent debate over the definition of a prebiotic, culminating in the recent clarification and simplification of wording by ISAPP. Looking forward, what does the future hold for prebiotics?

Read More

A Vision for the Second Green Revolution

There is a Second Green Revolution underway that is harnessing precision agriculture, no-till farming practices, biological, rather than chemical crop inputs and other new, innovative tools that improve soil health and water quality.

Read More

Understanding the Molecular Basis of Disease Resistance in Plants

There has been tremendous progress in understanding the molecular basis of disease resistance in plants in the last twenty years. However, translation of this knowledge into practical use has been slow.

Read More

Phytobiomes: Embracing Complexity to Achieve a New Vision for Agriculture

Imagine a world in which farmers have at their disposal analytical tools that help them determine the crop, management practices, and inputs to apply to a specific field in a given year, taking into consideration all physical (climate, soil…) and biological conditions (microbes, pests, disease, weeds, animals…)

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Biocontrol & Biostimulants: The Brightest Spots In Agriculture

Biocontrol and biostimulants hold the key to important agricultural benefits such as improved efficiency, increased yield and greater sustainability. 

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Novel Applications Of The Chloroplast Genome

Henry Daniell’s research analyses the crop chloroplast genome. In the past years, more than 40 crop chloroplasts genome were sequenced in his lab, including some of the most important crops such as coffee, orange, cotton and soybean.

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Probiotic Consortia Applications In Non-Sterile Soil

Plants feed microbial communities that, in return, provide the plant with growth hormones and antibiotics. Alexandre Jousset’s research focuses on probiotics consortia in tomato plant roots that form a shield defending plant tissues from Ralstonia solanacearum (Wei et al., 2015). This is an aerobic non-spore forming plant pathogenic bacterium colonising the xylem and causing bacterial wilt in its host. It can affect most world crop species including tomato, potato, banana and tobacco and there’s still no cure for this disease (Hu et al., 2016).

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The Wheat Genome Sequence Odyssey

As the world population is expected to reach 9.8 billion by 2050, it is crucial to have innovative genomics tools to address global food security in a sustainable way.

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Biofuels; The Energy Resource Of Our Future

Norman Lewis’ research currently focuses on the composition of phenylpropanoid metabolism pathway, which provides plants with neolignans and lignans. These are organic compounds giving structure and rigidity to the cell wall and allowing the normal growth and developments of plants. We interviewed him about his research.

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Network-Driven Drug Discovery – Circumventing the Limitations of Target-Driven Discovery

Over the past five years, e-Therapeutics have created a drug discovery engine based on a combination of large-scale, proprietary databases and a suite of computational tools. Small molecules are evaluated by their potential bioactivity in the search for better and more effective drugs to address unmet medical needs. This article outlines the core principles and advantages of the Network-Driven Drug Discovery (NDD) approach.

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Next Generation Sequencing Technology: An Open Letter From Mostafa Ronaghi

Dear Colleagues,

Launched in 1990, the Human Genome Project involved thousands of scientists across the globe and took 13 years to complete. Using capillary electrophoresis-based Sanger sequencing, it cost nearly $3 billion. In 2014 Illumina announced the first technology that could sequence a whole genome for less than $1,000.

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Challenges in Printing Hybrid Light Emitting Diodes

Organic Light Emitting Diodes (OLEDs)

Organic Light Emitting Diodes (OLEDs) are sub-micrometric devices formed by multi-stacked materials that have reached the appropriate Technological Readiness Level to be present in displays. Intense research has permitted the construction of diodes with long lifetimes, multi-colour emission and size variety.

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Enabling Flexible Displays and Sensors With Organic Electronics

While most conventional electronics are based on silicon transistors, there are other approaches being developed that seek to enable truly flexible components. At FlexEnable we believe the only way you can make truly flexible electronics is to start with truly flexible materials, so we use plastics (also referred to as organic materials) instead of ceramics to make our transistors.

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E-waste Recycling and Repurposing

Electronic waste (e-waste) is a fast growing problem. The UN estimates between 20-50 million tons of electronic waste is discarded every year, with only 12.5% of this being recycled. This leaves a colossal amount of e-waste sitting in landfill or improperly disposed of, which in turn leads to toxic materials leaching into the soil and water supply.

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Printed and Flexible Electronics: An Open Letter From Ton van Mol

Here at the Holst Centre, our technologies have matured in the last few years and our focus has expanded. We concentrate on application driven research, such as wearable health, automotive, the Internet of Things and solar energy.

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From Liquid Crystal Displays in 1996 to Microfluidics in 2016

Emmanuel Delamarche is a researcher at IBM Research who presented at our 2nd Microfluidics Congress about his research on precision diagnostics based on modular capillary-driven elements.

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