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  • Systems-Level Insights into the Synthetic Biology Congress

    Ernesto Andrianantoandro, Scientific Editor of Cell Systems, summarises his experience of the 3rd Synthetic Biology Congress.

  • Assays in Clinical Trials and Pharmacovigilance

    We chatted to Dr. John Chappell, Director of Large Biomolecule Analysis at LGC, Fordham UK, about developing analytical methods for measuring biologics to support clinical trials.

  • Translating Skin Microbiome Research into Clinical Products

    It has been demonstrated many times in the past that academia and industry, working in tandem, can achieve results to their mutual benefit much faster than when they work in isolation.

  • Bridging the Gap: Developing an SNP Panel to Understand Genetic Diversity of Modern Cannabis

    Phylos Bioscience focuses their research on understanding Cannabis genetic traits. Alisha Holloway directs the data science aspects of the company: analysing big data and transforming it into knowledge.

  • Enabling Flexible Displays and Sensors With Organic Electronics

    While most conventional electronics are based on silicon transistors, there are other approaches being developed that seek to enable truly flexible components.

The Potential Advantages of Digital PCR When Performing Molecular Measurement

Jim Huggett’s research focuses on molecular diagnostics, genomics and nucleic acids, including cancer and foetal genetic analysis and the diagnosis of infectious diseases. We interviewed him about the latest developments and the latest advances in qPCR research.

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Presidents, Rock Stars and Companion Diagnostics

President Jimmy Carter announced last spring that he no longer needed treatments for the metastatic melanoma found in his brain – after treatment with pembrolizumab (Keytruda, Merck), his physicians could no longer detect the cancer.

Read More

Stomata and Wounds: The Constant Dilemma of Pathogen Infection

Plant pests, together with abiotic stresses like drought, salinity and changes in temperature contribute to a constant loss in plant crops each year. Wound sites and stomata, represent the main entry pathogen sites.

Read More

Challenges in Printing Hybrid Light Emitting Diodes

Organic Light Emitting Diodes (OLEDs)

Organic Light Emitting Diodes (OLEDs) are sub-micrometric devices formed by multi-stacked materials that have reached the appropriate Technological Readiness Level to be present in displays. Intense research has permitted the construction of diodes with long lifetimes, multi-colour emission and size variety.

Read More

What does the future hold for Microfluidics?

Microfluidics technology has been applied and adopted across many areas of science and technology over the last 20 years, revolutionising the way patients are diagnosed, monitored and treated. Innovation remains very high in sample analysis and detection and progress has been boosted by the many new tools and procedures created in parallel to enable this.

Read More

Identifying New Probiotics Using In Vivo Models

Dysbiotic characteristics are increasingly attributed to a range of serious, and sometimes fatal, digestive disorders affecting humans. These include inflammatory bowel diseases, chemotherapy-induced mucositis, radiation enteritis, NSAID-enteropathy and colon cancer.

Read More

Modifying Plant Cell Walls to Produce Biofuels and Bioproducts

Biofuels and bioproducts are topics which have been particularly in vogue over the last decade. We spoke to Dr. Scheller who talked us through his findings on second-generation biofuels.

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Microbiome Research and Development: An Open Letter From Philip Hugenholtz

Dear colleague,

The structure and function of the human gut microbiome is being revealed through culture-independent molecular techniques. Many studies have found a great deal of interpersonal variability due to factors such as diet, age and ethnicity. However, there are a small number of relatively abundant microbial species that appear to be widespread in the human population.

Read More

The Potential Advantages of Digital PCR When Performing Molecular Measurement

Jim Huggett’s research focuses on molecular diagnostics, genomics and nucleic acids, including cancer and foetal genetic analysis and the diagnosis of infectious diseases. We interviewed him about the latest developments and the latest advances in qPCR research.

Read More

Presidents, Rock Stars and Companion Diagnostics

President Jimmy Carter announced last spring that he no longer needed treatments for the metastatic melanoma found in his brain – after treatment with pembrolizumab (Keytruda, Merck), his physicians could no longer detect the cancer.

Read More

What does the future hold for Microfluidics?

Microfluidics technology has been applied and adopted across many areas of science and technology over the last 20 years, revolutionising the way patients are diagnosed, monitored and treated. Innovation remains very high in sample analysis and detection and progress has been boosted by the many new tools and procedures created in parallel to enable this.

Read More

Identifying New Probiotics Using In Vivo Models

Dysbiotic characteristics are increasingly attributed to a range of serious, and sometimes fatal, digestive disorders affecting humans. These include inflammatory bowel diseases, chemotherapy-induced mucositis, radiation enteritis, NSAID-enteropathy and colon cancer.

Read More

Microbiome Research and Development: An Open Letter From Philip Hugenholtz

Dear colleague,

The structure and function of the human gut microbiome is being revealed through culture-independent molecular techniques. Many studies have found a great deal of interpersonal variability due to factors such as diet, age and ethnicity. However, there are a small number of relatively abundant microbial species that appear to be widespread in the human population.

Read More

Keith Kaplan and the future of digital pathology

Keith Kaplan is well known in the digital pathology circuit. A practising pathologist and author of the Digital Pathology Blog, he describes himself as an evangelist for the technology. We sat down with him at the Digital Pathology Congress, where he chaired a panel discussion, to get his thoughts.

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Systems-Level Insights into the Synthetic Biology Congress

The Molecular Biology Summit hosted three meetings in parallel: the qPCR and Digital PCR Congress, the Microfluidics Congress, and the Synthetic Biology Congress. Each meeting had talks organised into tracks which took place side-by-side. I attended the Synthetic Biology Congress, which also gave me access to the other two meetings.

Read More

Assays in clinical trials and pharmacovigilance

Assays are crucial during pre-clinical and clinical trials, and for pharmacovigilance. By this stage, the molecule has already been fully profiled with a mechanism of action, and efficacy and safety are now being assessed in vivo.

Read More

Stomata and Wounds: The Constant Dilemma of Pathogen Infection

Plant pests, together with abiotic stresses like drought, salinity and changes in temperature contribute to a constant loss in plant crops each year. Wound sites and stomata, represent the main entry pathogen sites.

Read More

Modifying Plant Cell Walls to Produce Biofuels and Bioproducts

Biofuels and bioproducts are topics which have been particularly in vogue over the last decade. We spoke to Dr. Scheller who talked us through his findings on second-generation biofuels.

Read More

Bridging The Gap: Developing An SNP Panel To Understand Genetic Diversity Of Modern Cannabis

At Phylos Bioscience we focus our research on understanding Cannabis genetic traits. I direct the data science aspects of our company, which includes the development of architecture for our automated analysis pipelines and statistical analysis of genetic variation data.

Read More

Genomics – Where to Next?

Since January 2008, the cost of sequencing a human genome has outpaced Moore’s Law, which states that computing power doubles every two years. It now costs less than $1000 USD to sequence a human genome to a coverage of 30x.

Read More

Plant Science and Agri-Genomics: The Importance of Collaboration

I love the saying, ‘if you want to go fast, go alone. If you want to go far, go together.’ This is so true in science and research. It takes diverse backgrounds and collaboration to deliver the best products. I find that complex answers are always found in diverse perspectives and collaborations.

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An Interview with Jane Fife: Promoting Plant Growth and Controlling Disease

Jane Fife has nearly 20 years of expertise in application technology and agricultural biologics. Joining  3Bar Biologics in 2016 as Chief Science Officer, her responsibilities include new product development and leading 3Bar’s long-term R&D portfolio.

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Developing Large-Scale Resources for Plant Functional Genomics

Ronan O’Malley has been working to develop large-scale mutant screening collections to identify causal genes within GWAS loci. His final goal is to integrate cistrome, epicistrome, genetic, and natural variant information to understand and ultimately predict how genome and epigenome sequence determines phenotypic outcomes. He spoke to us about his thoughts on plant genomics, bioinformatics and building large-scale resources for functional genomics.

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Working with PCR in agricultural research

Jean B. Ristaino has spent her career studying Phytophthora diseases of global importance, and has recently been awarded with the Excellence in International Service Award by the American Phytopathological Society for her achievements.

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Challenges in Printing Hybrid Light Emitting Diodes

Organic Light Emitting Diodes (OLEDs)

Organic Light Emitting Diodes (OLEDs) are sub-micrometric devices formed by multi-stacked materials that have reached the appropriate Technological Readiness Level to be present in displays. Intense research has permitted the construction of diodes with long lifetimes, multi-colour emission and size variety.

Read More

Enabling Flexible Displays and Sensors With Organic Electronics

While most conventional electronics are based on silicon transistors, there are other approaches being developed that seek to enable truly flexible components. At FlexEnable we believe the only way you can make truly flexible electronics is to start with truly flexible materials, so we use plastics (also referred to as organic materials) instead of ceramics to make our transistors.

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E-waste Recycling and Repurposing

Electronic waste (e-waste) is a fast growing problem. The UN estimates between 20-50 million tons of electronic waste is discarded every year, with only 12.5% of this being recycled. This leaves a colossal amount of e-waste sitting in landfill or improperly disposed of, which in turn leads to toxic materials leaching into the soil and water supply.

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Printed and Flexible Electronics: An Open Letter From Ton van Mol

Here at the Holst Centre, our technologies have matured in the last few years and our focus has expanded. We concentrate on application driven research, such as wearable health, automotive, the Internet of Things and solar energy.

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From Liquid Crystal Displays in 1996 to Microfluidics in 2016

Emmanuel Delamarche is a researcher at IBM Research who presented at our 2nd Microfluidics Congress about his research on precision diagnostics based on modular capillary-driven elements.

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