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  • Cross-Cultural Research into Microbiome Therapeutics for Cancer

    While microbiome therapeutics to support healthy gut function have garnered the lion’s share of attention, exciting approaches to oncology and anti-inflammatory therapeutics presage a new golden age for drug development.

  • Going Digital: A Norwegian Perspective on Pathology

    Inspired by the implementation of digital pathology in routine diagnostics in Sweden, Canada and the Netherlands, in Norway digitalisation projects are being organised. One of the pathologists working on these projects is Inger Nina Farstad.

  • Challenges and Applications in Using qPCR and Digital PCR for Environmental Samples

    Tiong Gim Aw’s investigation involves using NGS technology and metagenomics to study water security, microbial ecology and advanced biotechnology. His work examines new molecular methods for waterborne pathogens and source tracking techniques.

  • From PTI to ETI: An Overview of Plant Defence Response

    All plant cells are naturally exposed to bacteria and microbe colonisations. These can become pathogens when they invade the host cell to proliferate. However, successful penetration of the host cell is not an easy game.

  • Aflatoxin Binding by Probiotic Bacteria

    The health benefits of probiotics include the improvement of intestinal function, integrity and modulation of immunity. Furthermore, several studies have also suggested that probiotic bacteria and fermented dairy products possess anti-carcinogenic activity.

Applications of Digital Pathology: An Open Letter from Dariusz Borys

Dear Colleagues,

In the last decade, digital pathology has rapidly expanded to become an essential technology tool to support medical education, tissue based research, drug development, and the practise of clinical pathology.

Read More

The Human Microbiome in Focus: Probiotics, Modulation and Translation – Part 1

The 4th Microbiome R&D and Business Collaboration Forum: Europe explored microbiota both inside and outside the gut and examined the role of the human microbiome in various diseases with a focus on modulation and biotherapeutic translation.

Duc H. Le, UK Editor-in-Chief of EBioMedicine, summarises some of the presentations that took place on day one.

Read More

Pre-PCR: When Generating PCR-Compatible Samples Becomes Possible

Peter Rådström’s research is about the developments of pre-PCR processing, a method which aims to generate PCR-compatible samples. Diagnostic PCR is often limited by components that interfere with the amplification of PCR inhibitors and pre-PCR can overcome PCR inhibition without impairing the detection limit, addressing all steps leading to PCR amplification, samples treatment and PCR chemistry. This lowers the need for pure extracts, leading to simplified analysis processes and improved detection limits.

Read More

The Benefits of Whole Genome Sequencing for Microbiome Analysis

Over the last decade, there has been a huge shift in the popular perception of microorganisms – instead of considering them as potentially pathogenic organisms that should be destroyed, we now realise that the microorganisms living in and on us are an essential part of us and necessary for good health.

Read More

Shaped paper pumps for microfluidic devices

Glenn Walker, Associate Professor at North Carolina State University, is working with colleagues in the Department of Biomedical Engineering to develop low-cost, disposable pumps that can power a wide range of microfluidic devices. The pumps are made by laminating shaped pieces of commercially available filter paper, so they are inexpensive and easily fabricated by just about anyone.

Read More

PCR Applications In Host Residual DNA Samples

Host residual DNA (hrDNA) as an impurity in biologic drugs is currently quantified by DNA extraction followed by qPCR. Musaddeq Hussain developed a method for direct qPCR without using DNA extraction from mAb drugs. He gave us his view about the research and challenges of working in the field.

Read More

Breaking news: Philips receives FDA clearance for digital pathology solution

It has just been announced that the FDA has taken the long awaited step in the move towards wider use of digital pathology. Philips has received permission to market their IntelliSite Pathology Solution for primary diagnostic use in the United States. Is this the first step towards full acceptance of this technology as a front line diagnostic tool?

Read More

An open letter from George Whitesides

Dear Colleagues,

In the past decade, microfluidics has emerged as a distinct new field with the potential to influence subjects from chemical synthesis and biological analysis to optics and information technology.

Read More

Applications of Digital Pathology: An Open Letter from Dariusz Borys

Dear Colleagues,

In the last decade, digital pathology has rapidly expanded to become an essential technology tool to support medical education, tissue based research, drug development, and the practise of clinical pathology.

Read More

The Human Microbiome in Focus: Probiotics, Modulation and Translation – Part 1

The 4th Microbiome R&D and Business Collaboration Forum: Europe explored microbiota both inside and outside the gut and examined the role of the human microbiome in various diseases with a focus on modulation and biotherapeutic translation.

Duc H. Le, UK Editor-in-Chief of EBioMedicine, summarises some of the presentations that took place on day one.

Read More

Pre-PCR: When Generating PCR-Compatible Samples Becomes Possible

Peter Rådström’s research is about the developments of pre-PCR processing, a method which aims to generate PCR-compatible samples. Diagnostic PCR is often limited by components that interfere with the amplification of PCR inhibitors and pre-PCR can overcome PCR inhibition without impairing the detection limit, addressing all steps leading to PCR amplification, samples treatment and PCR chemistry. This lowers the need for pure extracts, leading to simplified analysis processes and improved detection limits.

Read More

The Benefits of Whole Genome Sequencing for Microbiome Analysis

Over the last decade, there has been a huge shift in the popular perception of microorganisms – instead of considering them as potentially pathogenic organisms that should be destroyed, we now realise that the microorganisms living in and on us are an essential part of us and necessary for good health.

Read More

Shaped paper pumps for microfluidic devices

Glenn Walker, Associate Professor at North Carolina State University, is working with colleagues in the Department of Biomedical Engineering to develop low-cost, disposable pumps that can power a wide range of microfluidic devices. The pumps are made by laminating shaped pieces of commercially available filter paper, so they are inexpensive and easily fabricated by just about anyone.

Read More

PCR Applications In Host Residual DNA Samples

Host residual DNA (hrDNA) as an impurity in biologic drugs is currently quantified by DNA extraction followed by qPCR. Musaddeq Hussain developed a method for direct qPCR without using DNA extraction from mAb drugs. He gave us his view about the research and challenges of working in the field.

Read More

Breaking news: Philips receives FDA clearance for digital pathology solution

It has just been announced that the FDA has taken the long awaited step in the move towards wider use of digital pathology. Philips has received permission to market their IntelliSite Pathology Solution for primary diagnostic use in the United States. Is this the first step towards full acceptance of this technology as a front line diagnostic tool?

Read More

An open letter from George Whitesides

Dear Colleagues,

In the past decade, microfluidics has emerged as a distinct new field with the potential to influence subjects from chemical synthesis and biological analysis to optics and information technology.

Read More

From PTI To ETI: An Overview Of Plant Defence Response

All plant cells are naturally exposed to bacteria and microbe colonisations. These can become pathogens when they invade the host cell to proliferate [1].

Read More

Ensuring Global Food Security: Genomic Approaches To Crop Diversity

As the world population is expected to reach 9 billion by 2050, global food security represents one of the most researched topics in plant science.

Read More

CRISPR/Cas9 Technology in Rice and Wheat

Genome editing (GE) technologies comprise a set of molecular tools that lead to the targeted modification of a specific DNA sequence within the genome of interest.

Read More

Applications of the CRISPR-System in Plant Resistance Breeding

Recent breeding strategies to improve crop resistance against pathogen attacks mainly rely on resistance genes. However, the genetic resource of resistance is limited in most crops, in particular in oilseed-rape (Brassica napus). However, breeding of resistance crops against new emerging diseases remains a great challenge.

Read More

Future Applications of Setaria: An Open Letter From Tom Brutnell

Dear colleagues,

As Director of the Enterprise Institute for Renewable Fuels, I oversee many projects at the Donald Danforth Plant Science Center with the goal of developing new technologies that will drive sustainable energy production using bioenergy grasses, algae and oilseed crops.

Read More

Stomata and Wounds: The Constant Dilemma of Pathogen Infection

Plant pests, together with abiotic stresses like drought, salinity and changes in temperature contribute to a constant loss in plant crops each year. Wound sites and stomata, represent the main entry pathogen sites.

Read More

Modifying Plant Cell Walls to Produce Biofuels and Bioproducts

Biofuels and bioproducts are topics which have been particularly in vogue over the last decade. We spoke to Dr. Scheller who talked us through his findings on second-generation biofuels.

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Bridging The Gap: Developing An SNP Panel To Understand Genetic Diversity Of Modern Cannabis

At Phylos Bioscience we focus our research on understanding Cannabis genetic traits. I direct the data science aspects of our company, which includes the development of architecture for our automated analysis pipelines and statistical analysis of genetic variation data.

Read More

Challenges in Printing Hybrid Light Emitting Diodes

Organic Light Emitting Diodes (OLEDs)

Organic Light Emitting Diodes (OLEDs) are sub-micrometric devices formed by multi-stacked materials that have reached the appropriate Technological Readiness Level to be present in displays. Intense research has permitted the construction of diodes with long lifetimes, multi-colour emission and size variety.

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Enabling Flexible Displays and Sensors With Organic Electronics

While most conventional electronics are based on silicon transistors, there are other approaches being developed that seek to enable truly flexible components. At FlexEnable we believe the only way you can make truly flexible electronics is to start with truly flexible materials, so we use plastics (also referred to as organic materials) instead of ceramics to make our transistors.

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E-waste Recycling and Repurposing

Electronic waste (e-waste) is a fast growing problem. The UN estimates between 20-50 million tons of electronic waste is discarded every year, with only 12.5% of this being recycled. This leaves a colossal amount of e-waste sitting in landfill or improperly disposed of, which in turn leads to toxic materials leaching into the soil and water supply.

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Printed and Flexible Electronics: An Open Letter From Ton van Mol

Here at the Holst Centre, our technologies have matured in the last few years and our focus has expanded. We concentrate on application driven research, such as wearable health, automotive, the Internet of Things and solar energy.

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From Liquid Crystal Displays in 1996 to Microfluidics in 2016

Emmanuel Delamarche is a researcher at IBM Research who presented at our 2nd Microfluidics Congress about his research on precision diagnostics based on modular capillary-driven elements.

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