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Precision Medicine

Multiplex Super-Selective PCR Assays for the Detection and Quantitation of Rare Somatic Mutations

Professor Fred Kramer spoke at the recent Research & Technology Series exploring Flow Cytometry / qPCR & Digital PCR / Liquid Biopsies. During his presentation, he explained how Super Selective primers enable the simultaneous identification and quantitation of rare somatic mutations in routine multiplex PCR assays, while virtually eliminating signals from abundant closely related wild-type sequences.

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Talking T cells

This article is republished with kind permission from BioVox.

BioVox got to speak with Prof. David Masopust, the man who discovered resident memory T cells. His seminal breakthrough opened up a new branch of T cell biology and catapulted the field forwards. Masopust shares his thoughts on the enormous untapped potential of T cells in new treatments and vaccines.

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Cell therapies: opportunities and challenges

This article is republished with kind permission from BioVox.

Recent activities in the cell therapy field have prompted many investment funds to pour fresh and increasing capital into this space. In this review, we would like to share some observations and highlight a few of the questions that arise when new modalities cross the bridge from bench to bed.

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Precision Medicine: Molecular Phenotyping, Diagnostic Development & Patient Subpopulations

As industry developments continue to improve, the potential for personalised medicine and the possibility of individual diagnosis is on the horizon. These slides, from the Precision Medicine & Biomarkers Leaders Summit: Europe are now available from Andres Hurtado-Lorenzo, Thorsten Gutjahr & Thomas Skot Jensen.

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Personalised Cancer Vaccines for Mesothelioma

Immunotherapy continues to gain popularity in several areas related to cancer research and new treatments. Studies prove that each and every cancer case is unique, so the need for personalised medicine presents a logical focus. Personalised cancer vaccines are one form of cancer immunotherapy. The vaccines are a form of precision medicine, which has become an increasingly more enticing area for treatment research.

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Pricing Pressure, Payer Perspectives and Innovative Diagnostic Platforms

We spoke to Alex Bastian about how he got started in precision medicine, where he sees it going and how he intends to use real world evidence to unlock the potential around personalised approaches to drug development:

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What’s been happening in precision medicine this month?

There has been some interesting news, discoveries and development to catch up on this month in the world of precision medicine. Take a look at the list below to find out more:

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The Challenges & Considerations of Reporting Somatic Variants in Cancer

Industrial and “omic” scale mutational profiling of solid tumours are possible as a result of massively parallel sequencing technology. However, these clinical genomic testing capabilities have also brought myriad new biological, technical and operational challenges not encountered in monogenic disorder testing. All of this impacts the interpretation and reporting of somatic variants. As a testament to the nascency of this field, the first published consensus guidelines for interpretation of variants in cancer was only released in early 2017.

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