TMB & Neoantigen

When

10th-11th Oct 2019
Registration from 8am

Where

London, United Kingdom
London Heathrow Marriott Hotel

Read the Agenda

TMB & Neoantigen Congress

EXPLORING ADVANCEMENTS IN NOVEL TARGETS, PREDICTIVE BIOMARKERS AND PERSONALIZED MEDICINE

Discover how experts are rising to the challenge of matching patients to the therapies that offer the greatest chance of success through innovative predicted biomarker and neoantigen research. Learn about the latest research on the tumour mutation burden and its potential for demonstrating the viability of immunotherapeutic treatment, as well as the development of other predictive biomarkers. A dedicated session will also examine the growing potential of neoantigens as novel targets for precision medicine

“I met leading companies/biomarker developers at one place sharing cutting edge technologies”.

“interesting mixture of topics; possibility to discuss with the attendees”

“Learned a lot from some of the talks”

THURSDAY 10TH OCTOBER 2019 – APPLICATIONS OF TMB AND NEOANTIGEN RESEARCH


Using Artificial Intelligence to accelerate Immunotherapy
JENS KRINGELUM, Director, Genomic Immuno Oncology, Evaxion Biotech, Denmark
• What is AI and how can it be used to predict immune responses in patients
• The use of AI driven prediction tools for design of novel immunotherapies
• Opportunities and challenges in using AI technology to drive truly personalised treatments

Will whole genome sequencing of fresh frozen tumour material become the assay of choice for cancer molecular diagnostics?
WILL SPOONER, Commercial Programme Delivery Lead, Genomics England, UK
At the start of the 100,000 Genomes Project it became clear that formalin fixed paraffin embedded tumour material was not suitable for whole genome sequencing. An alternative “WGS friendly” fresh frozen protocol (FF-WGS) was developed and implemented as a clinical pathway in the NHS. This protocol has been used to generate a dataset of linked genome-to-health data from 15,000 cancer cases. Analysis of the dataset suggests that our FF-WGS assay that has the potential to more reliably and accurately measure cancer markers such as TMB. This talk presents these data and considers the challenges of introducing FF-WGS-based tests into clinical
trials and practice. Finally, we speculate on the mining of large FF-WGS datasets to identify the next generation of cancer biomarkers.

PRESENTATION


Morning Refreshments / Poster Presentations


TMB and MSI in clinical application using comprehensive tumor profiling
MARTIN ZOCHE, Director Molecular Tumor Profiling, University Hospital Zurich, Switzerland
• Comprehensive molecular tumor profiling is standard at the University Hospital Zurich is as a diagnostic standard
procedure for all tumor patients.
• Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI) analysis are integrated in the molecular report
and discussed.
• Patient cases will illustrate the advantages for the tumor patients

ATLAS™ – A Critical Tool in Finding True Neoantigens
PAMELA CARROLL, Senior Vice President, Scientific Strategy, Genocea Biosciences, USA
• ATLAS™ is a powerful tool that screens all candidate neoantigens for pre-existing patient-specific CD4 or CD8 responses
in an HLA agnostic assessment.
• ATLAS also identifies inhibitory peptides that may suppress tumor immunity, accelerate tumor progression and mediate
patient response to immune checkpoint blockade therapies.
• ATLAS-selected neoantigens are the basis of a vaccine, GEN-009, currently being evaluated in Phase 1/2a clinical trials. Also, ATLAS is being applied to a personalized non-engineered T cell therapy program that targets multiple neoantigens.

PRESENTATION
An Integrated Machine-Learning Approach to Improve the Prediction of Clinically Relevant Neoantigens
• We will outline a high performing machine learning approach that predicts naturally presented antigens to the tumor cell surface
• The predictor, known as the Immuneoprofiler, is integrated with several immune parameters in a deep learning layer
• We illustrate the application of the Immuneoprofiler to significantly improve the identification of neoantigen targets for personalised cancer immunotherapy
Confirmed:
TREVOR CLANCY, CSO, NEC OncoImmunity AS

 


Lunch


Combined treatment with checkpoint blockade and Adenovirus vaccine targeting multiple neoantigens eradicates large tumors in mice
ELISA SCARSELLI, CSO, Nouscom, Italy
• Non-human Great Ape Adenoviruses (GAd) are potent vaccine vectors able to encode many neoantigens
• Vaccination synergizes with α-PD-1 in mice bearing large established tumours
• Combined treatment results in diversification of the intra-tumor T cell repertoire

Considerations and experiences from taking a fully personalized targeted cancer neoantigen DNA vaccine into the clinic
AGNETE FREDRIKSEN, President and CSO, Vaccibody, Norway
• What is the rationale to pursue development of individualized cancer vaccines and make it a viable product for the market?
• How does the vaccine format affect the immunogenicity profile of individual neoepitopes?
• Update from DIRECT-01, a clinical trial testing private cancer neoantigen based vaccines in patients with advanced cancer

 

Tailor-made immunotherapies: Integrating non-mutated and neoantigens into highly personalized
immunotherapy approaches
SARAH MISSEL, Director, Translational Development, R&D Strategy and Communications, Immatics, Germany
• The role of neoantigens and non-mutated antigens in tumors with low mutational burden
• GAPVAC – Actively Personalized Vaccination in newly diagnosed glioblastoma patients – results of the clinical study
GAPVAC-101
• Highly personalized Adoptive Cellular Therapy


Afternoon Refreshments / Poster Presentations


Viral-based vaccine for cancer neoantigen vaccination
KAÏDRE BENDJAMA, Project Leader, Personalized Cancer Vaccination, Transgene, France
Viral vectors constitute a promising modality for cancer vaccines. Viral vectors were used successfully to generate cancer vaccines in a number of indications using Tumor associated antigen as targets to induce a specific T cell response. The presentation will provide an overview on how Transgene uses the MVA viral strain to meet specific challenges related neoantigen vaccination from sequencing to neoepitope selection to manufacturing and QC to deliver a clinical grade product and on how these vaccines will be translated into the clinic in indications of high medical needs.


Networking Drinks Reception


Chromoplexis and chromothripsis can increase neoantigen load
GEORGE VASMATZIS, Co-director of the Biomarker Discovery Program, Associate Professor, Department of Molecular Medicine, Mayo Clinic, USA
• We observed that inter- or intrachromosomal rearrangements are present in many cancers frequently in a pattern of chromoanagenesis such as chromoplexy or chromothripsis.
• Transcription of rearrangement-related junctions was predicted to result in many potential neoantigens, some of which were proven to bind patient-specific major histocompatibility complex molecules and to expand intratumoral T cell clones.
• Subsets of prostate, lung, and breast, cancers as well as some sarcomas are among those that could present neoantigens that derive from complex rearrangements

PepPipe – an immunomics workflow elucidating antigenic peptide biomarker signatures for minimal invasive diagnostics
ANDREAS WEINHÄUSEL, Thematic Coordinator, Molecular Diagnostics, AIT – Austrian Institute of Technology, Austria
Autoantibody & antibody-profiles are biologically meaningful and suitable as early and minimal invasive markers using 10µl of plasma or serum. Since the immune system plays a major role in many diseases, sero-testing and immunomics analysis has a broad area of application and a high potential for diagnostics of autoimmune, cancerous, cardiologic, neurodegenerative and systemic diseases, as well as assisting biotech and pharma for selecting therapeutic targets or study off-target reactivities. PepPipe provides an entire workflow of optimised and QM qualified methods to define antigenic proteins and peptides for
serological analysis. We have developed a broad variety of assays with different multiplexing capacities to provide the entire workflow “from screening to validation” and “from proteins to peptides” to define and analyse antigenic proteins and peptides supporting clinical and therapeutic developments, and improving robust minimal invasive diagnostics.


Morning Refreshments / Poster Presentations


Optimising patient benefit whilst reducing toxicity risk
CHRISTOPHE LE TOURNEAU, Head, Department of Drug Development and Innovation (D3i), Institut Curie, France
Optimising patients benefit whilst reducing toxicity risk is the ultimate goal of precision medicine in oncology. While precision medicine has always been a reality in medicine with treatments adjusted based on the clinical condition of patients, the term “precision medicine” has arisen with the advent of molecularly targeted therapies that were developed based on biomarkers that were mostly DNA alterations. Precision medicine does not apply only for molecularly targeted therapies but also for immunotherapeutics especially immune checkpoint inhibitors, for which predictive biomarkers of efficacy have been identified at the genomic level.

Developing proteogenomcis platforms in cancers of high unmet clinical need
TEDD HUPP, Chair of Cancer Research, University of Edinburgh, UK
Proteogenomics platforms are being developed that can reveal the expressed cancer genome as we evolve towards personalized therapies. Our network aims to (i) define comprehensively the biological sources of cancer neoantigens; (ii) evolve algorithmic strategies for mass-spectrometry based mutation identification; (iii) identify novel genes that regulate MHC Class I production in cancers; and (vi) apply this knowledge on the mutant peptidome to form therapeutic options in cancers of high unmet clinical need.

Application of in vitro tools that improve selection of (neo)epitopes and characterize T cell responses
ASTRID VISSER, Business Development Manager, Sanquin, The Netherlands
• Measured peptide-MHC binding / stability that improves (neo)epitope selection
• Multi-parameter FACS that efficiently detects and characterizes multiple pre-existing and induced epitope-specific
T-cell responses
• Efficient peptide-MHC-exchange based assay that allows cross-reactivity and safety studies for peptide-MHCantibodies and TCR mimics


Lunch


Personalized NeoTCR-T Cell Therapies for Solid Tumors
ALEX FRANZUSOFF, CEO, PACT Pharma
PACT Pharma is developing personalized tumor-mutation (neoantigen or neoepitope) targeted T cells tailored for each patient. Using (non-viral) precision genome engineering, a fresh collection of autologous patient T cells are reprogrammed to produce ‘native’ autologous tumor mutation-targeted T cells (neoTCR-T cells) for administration as a ‘living drug’ back to the patient. In this talk, I will discuss PACT’s development of neoTCR-T cell products exclusively for each patient, as well as the remarkable landscape of neoE-specific T cells (direct capture) in blood or TILs of patients, as well as the evolution of neoE-T cell responses in I-O trials. These developments represent a new frontier for programming fresh, autologous human T cells with ‘new tricks’ to personalize the treatment of patients with the spectrum of solid tumors.

Profiling of neo-antigens presented by cancer cells facilitate patient stratification and development of potent antitumor therapies
TIM FUGMANN, Senior Scientist, Max Delbrück Center and Senior Scientific Advisor, Alithea Bio, Switzerland
• Aberrantly expressed transcripts lead to presentation of neo antigens on cancer cells
• Aberrant expression is a common event leading to antigens shared between multiple tumors
• Such neo antigens can be targeted by adoptive T cell therapies


Chair’s Closing Remarks / Conference Close


 

Agenda

Attracting over 250 experts this meeting will appeal to those working to develop technologies that will meet the challenge of matching patients to the therapies that offer the greatest chance of success, thereby increasing efficacy in response to the individuals’ circumstances.

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Venue

London Heathrow Marriott Hotel

London Heathrow Marriott900

Bath Road, Harlington, Hayes, Middlesex, UB3 5AN

Group room rate £159 inclusive of breakfast and tax.

Pricing & Registration

Applications for a free place

There are some terms and conditions to meet, but nothing too onerous. A free pass gives you all the benefits detailed opposite.

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The conference fee includes:
  • All conference sessions
  • Lunches and refreshments
  • Access to exhibition room
  • All networking forums
  • Conference workbook
  • e-documentation pack
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Poster Presentations

Poster presentation sessions will take place in breaks and alongside the other breakout sessions of the conference. Your presentation will be displayed in a dedicated area, with the other accepted posters from industry and academic presenters.

We also issue a poster eBook to all attendees with your full abstract in and can share your poster as a PDF after the meeting if you desire (optional).

Whether looking for funding, employment opportunities or simply wanting to share your work with a like-minded and focused group, these are an excellent way to join the heart of this congress.

In order to present a poster at the forum you need to be registered as a delegate. Please note that there is limited space available and poster space is assigned on a first come first served basis (subject to checks and successful registration).

We charge an admin fee of £100 to industry delegates to present, that goes towards the shared cost of providing the poster presentation area and display boards, guides etc. This fee is waived for those representing academic institutions and not for profit organisations.

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We will require the form (downloadable below) to be submitted by the 20th September. This is the formal deadline however space is another limiting factor so early application is recommended.  Therefore please contact us with any questions you have as soon as possible

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Twenty-Minute Prearranged One-to-One Meetings

Select which delegates you would like to meet in a series of prearranged twenty-minute one-to-one meetings, held during breakout sessions from the main conference agenda. Our conference team will be available at the sessions to ensure all your meetings take place on time. 

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Showcase your technologies and products throughout the conference in the dedicated exhibition areas where all refreshment breaks and lunches take place, as well as the networking drinks reception at the end of day one.

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Telephone +44 (0) 1865 849841 or
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TMB & Neoantigen Congress

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