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Skin Commensals and T cells: How Do We Keep the Peace?

Skincare

Tiffany Scharschmidt spoke to us about her thoughts on the skin microbiome, immune responses and inflammatory skin diseases.

Our Work

In my role as a dermatologist, I specialise in the care of patients with severe inflammatory skin disease, and as a physician-scientist, I have combined training in both microbiology and immunology. Both in the clinic and the lab, my passion is to try to understand how our adaptive immune system establishes and maintains a healthy relationship with the commensal bacteria on our skin, and how this symbiosis is altered in inflammatory skin disorders.

Our skin is coated with billions of these healthy non-pathogenic bacteria and contains an equal number of T cells. These T cells protect us from infection by recognising and responding to microbial pathogens. A basic question that drives my work is why does healthy skin show no evidence of inflammation directed against commensal bacteria?

Using a new model to study the CD4 T cell response to a skin commensal bacteria, we recently discovered that exposure to a commensal bacteria during neonatal, but not adult life, leads to immune tolerance. We also identified that an abundant population of activated regulatory T cells (Tregs) enter the skin in neonatal life and mediates this commensal-specific tolerance. Our work is currently focused on dissecting how commensal skin bacteria and molecules facilitate host tolerance.

My Motivation

Inflammatory skin diseases affect billions of people worldwide. I see these patients day in and day out in my clinic and I can tell you these disorders are highly debilitating. Their pathogenesis is clearly complex, but we now recognise that aberrant immune responses to skin bacteria play a central role. It is my hope that our efforts to understand mechanisms that regulate the adaptive immune response to skin commensals will one day translate into a new class of therapeutics that harness microbial molecules to modulate the cutaneous immune response.

I find it deeply gratifying to be able to combine patient care with research pursuits aimed at improving our understanding and treatment of the inflammatory skin diseases from which my patients suffer.

The Changing Field

As a medical student, I worked in the lab of Julie Segre at NHGRI. It was during this period 10 years ago that Julie and her collaborator, Heidi Kong, began studies to characterise the skin microbiome using sequencing techniques. Since then, their groups and others have transformed our understanding of the bacterial, fungal and viral communities that live in healthy and diseased skin. Concurrent work by Yasmine Belkaid’s, Rich Gallo’s and other groups, have begun to functionally dissect the role of these microbes in promoting homeostatic functions of the skin epithelium and skin-resident immune cells.

I view this as a tremendously exciting time to be in the skin microbiome space. Admittedly, we are a decade or so behind the gut microbiome field in our development, but I believe the skin microbiome is of critical importance to health and represents an optimal target for therapeutic intervention. While the last decade of work has focused on identifying who the key microbial players are in the skin, I believe work moving forward will increasingly focus on understanding the role of these microbes in skin health and the mechanisms by which they exert their effects. I look forward to being a part of this exciting effort.

tiffanyscharscmidt


Tiffany Scharschmidt
is a dermatologist and physician-scientist at UCSF. In the clinic, she specialises in the care of patients with severe inflammatory skin disease. In the lab, she has combined training in immunology and microbiology.


Read more articles on the microbiome.

One Response to “Skin Commensals and T cells: How Do We Keep the Peace?”

  1. steve schnittger

    Tiffany – thanks for a great article. I am in charge of Microbiology and Fermentation R&D for the Estee Lauder Companies in NY and we have done work with Lactobacillus ferment and have found some interesting findings but we are trying to see how it translates into a measurable benefit when dealing with healthy skin versus that which is diseased or compromised such as acne, atopic, rosacea etc. if you ever get to the east coast I would love to invite you out to the lab for a discussion
    steve

    Reply

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