UK +44 (0)1865 849841
Malaysia +60 3 2117 5193

The Genetics of progressive NAFLD

Over the last decade, the understanding of genetic factors impacting progressive liver disease has greatly increased. At the 2nd Global NASH Congress, Associate Professor at the University of Milan, Luca Valenti’s research showed the I148M variant of PNPLA3 to be the main common genetic determinant of NAFLD, and how this discovery can be translated into therapeutic approaches.

Multi-ethnic epidemiological studies such as the Dallas Heart Study have provided evidence that genetics play an important role in the pre-disposition to liver disease.

Subsequent physiological studies have identified the key determinants in the major pathways associated with NAFLD. These concern the uptake of substrates such as glucose, and the activation of glycolysis, lipogenesis, lipid oxidation, lipid secretion, and the remodeling of lipids leading to lipotoxicity and fibrogenesis.

In his presentation, Luca demonstrated how impaired lipid droplet remodeling causes NASH in PNPLA3 I148M carriers, and how the genetic variant is a major predictor of liver fibrosis. He then looked at other genetic variants and the associated pathways relevant to the development of progressive liver disease.

To discover what those other genetic factors are and how they impact the development of NASH, take a look at the slides available below.

Genetics of progressive nonalcoholic fatty liver disease
Hepatic fat accumulation and nonalcoholic fatty liver disease (NAFLD), especially the progressive form of the disease, have a strong heritable component. Luca Valenti discusses I148M variant of PNPLA3 is the main common genetic determinant of NAFLD.

View the slides

 

For access to more resources on NASH and NAFLD, visit our resources page.

Leave a Reply

Subscribe to Our Newsletter

Get free reports and resources from our world class speakers.
  • This field is for validation purposes and should be left unchanged.

Life Sciences Twitter Feed

Archive