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NASH Resources

Welcome to the NASH resources page: a curated list of presentation slide decks.

These resources were produced from our NASH series of events. The next related conference is:

Presentation Videos

Inhibiting NOX enzymes to treat mulitple diseases with high medical need

Alexandre Grassin

The EMA reflection paper on chronic liver disease and its implications for drug development in NASH

Elmer Schabel

Genetics of progressive NAFLD

Luca Valenti

Poster Presentations

Development of a diet-induced disease-mimicking in vitro model of non-alcoholic steatohepatitis / fibrosis

Haysam Ahmed, Hossein Eslami Amirabadi, Karin Toet, Elsbet Pieterman, Robert Ostendorf, Roeland Hanemaaijer, Evita van de Steeg, Bob de Water, Ivana Bobeldijk and Geurt Stokman

Presentation Slides

Targeting different pathways of NASH pathogenesis using single and combination therapies

Eric Hughes, Global Development Unit Head, Immunology & Dermatology, Novartis

Modulation of the mitochondrial pyruvate carrier (MPC) as a treatment for NASH

Jerry R. Colca, Vice President for R&D, Cirius Therapeutics

Body composition in NASH clinical trials

Jonathan Riek, Vice President of Musculoskeletal & Metabolic Imaging, BioTelemetry Research

Liver biopsy as the gold standard for diagnosis

Pierre Bedossa, President of the European Society of Pathology

FDA Regulatory considerations for NASH clinical trial endpoints

Stephanie O. Omokaro, Lead Medical Officer, DGIEP Liver Team IV, Center for Drug Evaluation and Research, Food and Drug Administration

Imaging based technologies for NAFLD in clinical practice

Victor de Ledlinghen, Professor, Investigation Center of Liver Fibrosis, Bordeaux University Hospital

GKT831: A novel PII anti-fibrotic small molecule

Alexandre Grassin, VP Finance and Administration, Genkyotex. Switzerland

The EMA reflection paper on chronic liver disease and its implications for drug development in NASH

Elmer Schabel, Clinical Assessor, Licensing Division 2, Federal Institute for Drugs and Medical Devices (BfArM), Germany

Genetics of progressive nonalcoholic fatty liver disease

Luca Valenti, Associate Professor of Internal Medicine, University of Milan, Italy

Application of non-invasive tests for liver fibrosis

William Rosenberg, Peter Scheuer Chair in Liver Diseases, Deputy Director, UCL Institute for Liver and Digestive Health

Discovery and validation of protein signatures for NAFLD risk and NASH status

Stephen Williams, Chief Medical officer, SomaLogic

The Poxel NASH portfolio: PXL770 and PXL065 two Differentiated Drug Candidates with Complementary Mechanisms of Action for the Treatment of NASH

Sebastien Bolze, Executive Vice President, Non Clinical Development, Co-Founder, Poxel

Dual GLP-1 Agonists in the Treatment Metabolic & Liver Dysfunction in NASH

Scott Harris, Chief Medical Officer, Altimmune

Multiparametric MRI for the evaluation of NAFLD

Michael Pavlides, Head of Liver Imaging, Oxford Centre for Clinical Magnetic Resonance Research (OCMR)

Sustained FXR agonist as optimized, best-in-class treatment for NASH

Hubert Chen, Chief Medical Officer, Metacrine

Identifying patients with risk of adverse outcomes – where should we look more closely?

Hannes Hagström, Consultant in Hepatology, Unit of Hepatology, Karolinska University Hospital, Sweden

The role of lysosomal acid lipase activity in NAFLD/NASH pathogenesis

Stefano Ginanni Corradini, Associate Professor,Division of Gastroenterology, Department of Translational and Precision Medicine, University “Sapienza” of Rome Italy

NASH Trial Recruitment: The AES Solution

Elias Ketiar, Medical Director, Accelerated Enrollment Solutions

RNAi strategy for the treatment of NASH: focus on astrocyte elevated Gene-1 (AEG-1)

Devanand Sarkar, Professor, Virginia Commonwealth University, USA

Metabolic changes and biomarkers preceding and associated with NASH

Daniel Sikkema, Vice President, Accelerator and Pharma services for Quanterix Corporation

How the gut talks to the brain to impact the liver

Carel le Roux, Professor of Experimental Pathology, Conway Institute, Diabetes Complications Research Centre, University College Dublin, Ireland

Diabetes and NAFLD: a vicious spiral affecting both diseases

Chris Byrne, Professor Endocrinology & Metabolism, Human Development and Health Academic Unit, Faculty of Medicine, The \Institute of Developmental Sciences (IDS), University of Southampton, UK

The impact of medical devices on diabetes and fatty liver disease

Alex Miras, Senior Clinical Lecturer in Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College, UK

Resmetirom, a highly beta selective liver-directed thyroid hormone receptor beta agonist for the treatment of NASH

Rebecca Taub, Chief Medical Officer and President, Research & Development, Madrigal Pharmaceuticals, USA

Endpoint Adjudication Best Practices for NASH trials

Bindi K. Shah, Chief Medical Officer, WCG – ACI Clinical