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Tag: biotherapeutics

Augustine Therapeutics: Bridging the Valley of Death with VIB Discovery Sciences

This article is republished with kind permission from BioVox.

Augustine Therapeutics is one of VIB’s latest spinoffs, developing a first-in-class drug for Charcot-Marie-Tooth disease. The company recently announced a seed-funding round of €4.2 million, led by V-Bio Ventures. We spoke to several of the key persons in Augustine about how the startup is tackling the “Valley of Death”: the no-man’s-land between academia and industry where many potential therapies often fail.

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Gut Microbiome analysis – Getting it right

The cascade of new discoveries relating health and disease to our gut microbiome has spurred the notion that we now find ourselves in the middle of a “microbiome revolution”. Just to mention some recent examples, mechanisms have been demonstrated for gut bacteria contributing to Parkinson’s disease,[1] determining response to immune checkpoint inhibitor cancer therapy,[2] and even autistic behavior when fecal material from autistic children was transplanted into mice.[3]

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What are the main bottlenecks for realising continuous manufacturing?

Bioprocesses are traditionally performed in (fed-) batch processes for the production of various recombinant proteins and therapeutics. Batch processing comprises of processes where the material flow has hold steps in between two unit operations where the product is recovered from each unit operation step. However, such batch processes are attributed to longer process time and costs, and inconsistent process performance.

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Antibody Drug Conjugates: Bioanalytical Assay Challenges and Strategies

Antibody-drug conjugates (ADCs) combine the high specificity of a monoclonal antibody (mAb) for a target antigen with the highly potent cytotoxic activity of small-molecule drugs. Although the concept behind ADCs is relatively simple, the successful design and development of ADCs is a complex task. Similar to other biotherapeutics, the understanding of Pharmacokinetics (PK), Pharmacodynamics (PD), and Absorption, Distribution, Metabolism, and Excretion (ADME) properties of ADCs is critical for their successful development.

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