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Tag: CRISPR

How CRISPR will guide the way to better cancer therapies

This article was originally published on Open Targets and is republished with kind permission.

For many cancers we don’t have an effective treatment option, and worse still, a lot of the therapies that we use are just not good enough. We need better cancer therapies, and we need them now.

The reason we need new therapies is actually the reason why I got into cancer research. It goes back to when I was only 17 when my Mam was diagnosed with acute myeloid leukemia (AML). She went through her treatment, chemotherapy, with another 12 patients, and unfortunately she was the only one who survived.

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The Top 5 Plant Genomics Articles of 2018

It has been an eventful year for plant genomics: we’ve seen advancements in plant disease research, the sequencing of the wheat genome, which was finally achieved through a worldwide collaboration of researchers spanning 13 years, and the ruling on the legal status of gene-edited crops. 

As 2018 draws to a close, we thought it was a good time to reflect. Here, we’ve collated our top articles of the year.

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Microbiome within Plants, the Rhizophagy cycle and metagenomic discovery strategies

As a result of revolutionary breakthroughs in recent years, plant research has evolved dramatically. At the 6th Plant Genomics & Gene Editing Congress: USA, the latest NGS, “omic” and gene editing technologies being used for progressing plant based research were examined. If you weren’t able to be there in person, these slides are now available from Sharon Doty, James White & Axel Visel.

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To regulate or not to regulate: Current legal status for gene-edited crops

Gene editing is the latest and sexiest DNA editing tool in the continuum of plant breeding innovations. With genetically modified organism (GMO) technology, scientists introduce “foreign” genes, i.e. genes from a different organism, into crops. With gene editing, scientists create additional genetic variation by making precise changes to the existing crop’s genome. It offers great opportunities, but also creates regulatory challenges.

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What’s Next for Plant Genomics?

2017 is drawing to a close and it’s about that time where we begin to reflect. It has been a huge year for plant genomics in terms of technological advancements in the field with two developments in particular: CRISPR and disease resistance.

Successful sequencing, along with the improvement of biological data sets, have given plant scientists the tools and knowledge to make exciting developments to benefit agriculture. Research in plant disease resistance is being used to tackle global issues, such as food security, and novel gene editing technologies like CRISPR will take this research even further. 

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The Development and Application of CRISPR-Cpf1

Genome editing is slowly causing, or has perhaps already caused, a paradigm shift in the world of agriculture and in plant genomics in general. The ability to precisely and easily edit genes has never been as widespread before as it is now. The technology is causing a momentous shift towards using genome editing to not only validate gene function but also to create better crop varieties for the sustenance of a growing human population.

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Engineering the Microbiome – the Next Frontier

Microbial ecology, our understanding of what determines the robustness and community dynamics of microbial consortia, and synthetic biology, the art of engineering microorganisms to perform particular physiological or metabolic functions, are rapidly becoming allies in the race to develop novel therapeutic strategies in the microbiome space.

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CRISPR: From Early Discoveries to Applications in Plant Science

The discovery of CRISPR happened by accident in 1987. First applied in mammalian cells in 2013, a year later it was applied to plant cells. Our timeline highlights the milestones of this novel technology until its most recent developments and applications in plant science.

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