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Tag: sequencing

The grass has never been greener for engineering plant immunity and resilience

Scientific research is always working at the frontiers of knowledge, but plant genomics technologies have had a dramatic impact on plant science even by our standards. The wide availability of sequencing technologies has been a rare step-change that has unlocked knowledge in a way nobody in the field could have imagined twenty years ago. Knowledge which could make a considerable contribution to food security in the face of changing climates.

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Case Study: High-throughput SNP Screening Downstream of CRISPR/Cas9 Gene Editing

One of the most powerful applications of genome editing is the introduction of nucleotide substitutions in specific genomic sites. This can be used to mimic single-nucleotide polymorphisms (SNPs) or to generate stop codons that yield precise gene knockouts. However, screening hundreds of clones for a single edited nucleotide remains a challenge, especially in the absence of a corresponding phenotype.

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Research and business opportunities in clinical microbiomics

This article was originally published in Health Europa Quarterly on 3 May 2018, and is published here with permission.

Exploring areas of research and development related to the microbiome – the collective name for the micro-organisms living in the human body – is the central topic of the annual Microbiome R&D Business Collaboration Forum. This year’s focus at the event was on business collaboration and private investment into research and development projects in the microbiome.

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Is Palm Oil Sustainable for People?

Palm oil belongs to Elaeis, which is the only genus of Arecaceae family that produces edible oil. The current commercial planting is mainly E. guineensis, (Jacq.) originating from West Africa, selected due to its yield superiority. The cultivations occur throughout the tropical belt, especially in Southeast Asia, Africa and South America. To date, palm oil has become the most important oil crop in the world, accounting for 37% of global vegetable oil production. However, palm oil sustainability is always debated. Is palm oil really sustainable for people? To answer this, some facts are worth pondering.

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The Challenge of Accurately Performing Skin Microbiome Metagenomic Studies

The human skin is densely colonised with a complex microbial community (1). Microbes are a part of the skin barrier that, combined with  innate immunity, keeps the balance essential to maintaining healthy skin (2). Recent and independent research projects strongly suggested that human skin microbiota is of a major importance for human health and could be targeted to improve the skin health.

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Early And Present Applications Of CRISPR/Cas9

Genome editing technologies are a type of genetic engineering leading to the targeted modification of the genome of interest via the insertion, deletion or replacement of specific DNA sequences [1]. Amongst these, CRISPR/Cas9 is certainly the most promising and plant researchers have quickly realised its importance as its use is applied to several plant species [2, 3].

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The Benefits of Whole Genome Sequencing for Microbiome Analysis

Over the last decade, there has been a huge shift in the popular perception of microorganisms – instead of considering them as potentially pathogenic organisms that should be destroyed, we now realise that the microorganisms living in and on us are an essential part of us and necessary for good health.

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Development of ecosystems for precision medicine

The genomic and post-genomic age promises much for clinical medicine, largely because we can now comprehensively sequence genomic DNA to identify polymorphisms, patterns and mutations. We can also measure gene expression routinely and systematically and with high sensitivity measure the amounts of proteins produced.

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