Multiplex Super-Selective PCR Assays for the Detection and Quantitation of Rare Somatic Mutations
Posted 22nd February 2021 by Nicholas Noakes
Professor Fred Kramer spoke at the recent Research & Technology Series exploring Flow Cytometry / qPCR & Digital PCR / Liquid Biopsies. During his presentation, he explained how Super Selective primers enable the simultaneous identification and quantitation of rare somatic mutations in routine multiplex PCR assays, while virtually eliminating signals from abundant closely related wild-type sequences.
AI use in clinical diagnosis
Posted 19th February 2021 by Nicholas Noakes
Deep learning tool predicts tumour expression from whole slide images
A deep learning model to predict RNA-Seq expression of tumours from whole slide images was among the industry innovations outlined at the 7th Digital Pathology and AI Congress for Europe. Created by French-American start-up Owkin, the detail of how the company’s HE2RNA model provides virtual spatialization of gene expression was detailed to online delegates by senior translational scientist Alberto Romagnoni who highlighted its use in clinical diagnosis. During his presentation, delegates heard how Owkin has collaborated with doctors, hospitals and academic institutions to develop the tool.
Machine learning advances diagnostics and prognostics
Posted 10th February 2021 by Nicholas Noakes
Computerized image analysis can predict cancer outcomes
The advent of digital pathology is offering a unique opportunity to develop computerized image analysis methods to diagnose disease and predict outcomes for cancer patients from histopathology tissue sections. Such advances can help predict the risk of recurrence, disease aggressiveness and long-term survival, according to a leading expert in the field, Professor Anant Madabhushi from Case Western Reserve University in Ohio.
Vaginal Microbiota Management and Impact on Women’s Health
Posted 9th February 2021 by Nicholas Noakes
Speaking at the 7th Microbiome & Probiotics Business Collaboration Forum, Liisa Lehtoranta explored the future possible directions for vaginal microbiome research.
Telepathology for second opinion teleconsultation
Posted 2nd February 2021 by Nicholas Noakes
Speaking at the 2020 Digital Pathology Congress Liron Pantanowiz reviewed why he thought telepathology is the number one application for digital imaging. In this blog, we report what he had to say about telepathology for second opinion teleconsultation.
Telepathology in the acute care setting
Posted 19th January 2021 by Nicholas Noakes
Speaking at the 2020 Digital Pathology Congress Liron Pantanowiz reviewed why he thought telepathology is still one of the key applications for digital imaging. In this blog, we report what he had to say about telepathology in an acute care setting and the importance of validation.
Talking T cells
Posted 28th October 2020 by Joshua Sewell
This article is republished with kind permission from BioVox.
BioVox got to speak with Prof. David Masopust, the man who discovered resident memory T cells. His seminal breakthrough opened up a new branch of T cell biology and catapulted the field forwards. Masopust shares his thoughts on the enormous untapped potential of T cells in new treatments and vaccines.
Harvesting the power of the cell’s own protein degradation mechanisms in drug discovery
Posted 21st October 2020 by Joshua Sewell
Constant production of proteins in living cells is subject to strict quality and concentration control. The ubiquitin-protease system (UPS) is one of the systems responsible for degrading misfolded and damaged proteins. Also, short-lived regulatory proteins that control many critical cellular processes, including cell cycle progression, cell proliferation and differentiation, cell signalling and transcription are degraded by UPS.1
