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Life Science

Conversation with Dr Hamid Tizhoosh, Founder of KIMIA Lab and Leading Expert in the Development of Unsupervised AI for Tissue Pathology

What we have to learn from day one when we design these AI applications, is that pathology has to come with us. We cannot just design a network as computer scientists and then go to the pathologists just when we need to validate it. The pathologist has to be with us from the start.

Dr Hamid Tizhoosh

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A Paradigm Change in Skin Health

There has been a rapid acceleration of skin microbiome research. Today about 5% of all microbiome clinical studies and 16% of all probiotic products online are dermatology related. Meanwhile, skin probiotics are growing eight times faster than any other probiotic supplement. In clinical cosmetic studies, the microbiome is the fourth largest category.

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Conversation with one of the founders of modern digital pathology

“Digital pathology has reached the point where if you don’t have digitized slides, you will not be able to do six out of ten things that other pathologists can do today.”

Dr. Anil Parwani

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Drug Development for NASH with Fibrosis: Expedited Programs

George Makar spoke at the Global NASH Congress. He gave a regulatory perspective on Drug Development for NASH with Fibrosis. The views were his own. In part one, we explore expedited programs.

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Gut dysbiosis in clinical Huntington’s Disease

Speaking at the recent Microbiome R&D and Business Collaboration Forum, Anthony Hannan explored research using mouse models for brain disorders, particularly in Huntington’s disease (HD), schizophrenia, depression, and anxiety disorders. He also examined the role of gene-environment interactions involving mental activity, physical activity, stressors, and diet.

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Circulating biomarkers in melanoma immunotherapy

Genevieve Boland, speaking at the Research & Technology Series, described the translational research conducted at her laboratory. Using tumour and blood samples from patients before treatment, at meaningful clinical changes, progression, and post-mortem she, and her team are trying to understand the biology of Melanoma to treat patients better.

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Guidelines for Validating Whole Slide Imaging for Diagnostic Purposes

Andrew Evans, speaking at the Digital Pathology & AI Congress USA, described new guidelines he helped to draft for validating whole-slide-imaging for diagnostic purposes. First published in 2013 the guidelines were designed to address the fundamental question, “what needs to be done to validate a whole slide imaging for diagnostic use?”. The review producing the new guidelines was published in May 2021.

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Using the abYsis database for drug discovery

Professor Andrew Martin, UCL, speaking at the 4th Global Pharma R&D AI, Data Science and Informatics Summit, described using the abYsis database and workbench for drug discovery. He showed how it is possible to explore an annotate antibody sequence and structure, including comparisons with observed residue distributions. The database can also aid with humanization by making sequences more human and library design.

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