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Continuous or intensified bioprocessing? The gold standard for improved productivity

Process intensification and continuous biomanufacturing continue to attract a lot of interest within the biopharmaceutical industry as a method that can increase productivity and make the most efficient use of production assets.

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What are the main bottlenecks for realising continuous manufacturing?

Bioprocesses are traditionally performed in (fed-) batch processes for the production of various recombinant proteins and therapeutics. Batch processing comprises of processes where the material flow has hold steps in between two unit operations where the product is recovered from each unit operation step. However, such batch processes are attributed to longer process time and costs, and inconsistent process performance.

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