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Microbiome

Microbiome-based interventions – a labyrinth of modalities

Microbiome-based interventions, whether therapeutic or prophylactic, come in a broad spectrum of modalities, a consequence of the complexity of and possibilities afforded by the microbiome.

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Ask not “what your gut microbiome can do for you”, but “what you can do for your gut microbiome”

Defined health outcomes are increasingly being linked to prebiotic ingredients and supplements. For example, mounting evidence recently led the FDA to issue a qualified health claim regarding the ability of digestion resistant starch to reduce the risk of type 2 diabetes. With the direct annual cost of diabetes recently estimated to be $825B (1), the potential application of prebiotics to reduce disease risk is appealing from both health care and business investment perspectives.

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The Best Microbiome Articles of 2017

2017 has been another big year for microbiome research. Not only is funding at an all-time high but the shift from 16S to whole-genome sequencing means that we are able to deduce the role it plays in health more effectively.

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Seeking Elusive Microbiome Standards

“The two reports chart the ecological landscape of microbiome methods ‘in the wild’ and should engender a newfound sense of urgency to optimize methods and to improve reproducibility between laboratories.”

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What’s New With Prebiotics?

A prebiotic is defined as “a substrate that is selectively utilised by host microorganisms conferring a health benefit”. This updated consensus definition from the International Scientific Association for Probiotics and Prebiotics expands the application outside the digestive tract.

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The Case and Need for a Digital Health Ecosystem

The current healthcare climate is on the brink of a long overdue makeover. The clinical research industry has been increasingly plagued by a resistance to change and is subsequently feeling the pain of this reluctance to modify its approach. Indicative of this trend are the rising prices of drug and medical device development, declining patient retention and adherence in clinical research, mounting administrative burdens, and exponentially growing expenses for clinical research that are unsustainable.

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The Future of Prebiotics

There has been much recent debate over the definition of a prebiotic, culminating in the recent clarification and simplification of wording by ISAPP. Looking forward, what does the future hold for prebiotics?

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The Challenge of Accurately Performing Skin Microbiome Metagenomic Studies

The human skin is densely colonised with a complex microbial community (1). Microbes are a part of the skin barrier that, combined with  innate immunity, keeps the balance essential to maintaining healthy skin (2). Recent and independent research projects strongly suggested that human skin microbiota is of a major importance for human health and could be targeted to improve the skin health.

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