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August’s Best Open Access Synthetic Biology Journal Articles

Synthetic biology journals

Isn’t it frustrating when you follow a great piece of research back to the publisher, but can’t read it? We’ve compiled 7 of the best synthetic biology journal articles of August and better yet, they’re open access.

1. Spacial dynamics of synthetic microbial mutualists and their parasitesPLOS Computational Biology

Hypercycles are examined through using engineered synthetic cooperative strains of microbes that grow and interact in a cell culture either in the presence or absence of synthetic parasitic strains.

2. The de novo synthesis of horsepox virus: implications for biosecurity and recommendations for preventing the reemergence of smallpox, Health Security

Following the first de novo synthesis of an orthopoxvirus – a group that includes horsepox and the variola virus – biosecurity and the potential threat to global health security is discussed.

3. Model-based design of RNA hybridization networks implemented in living cellsNucleic Acids Research

A novel strategy for implementing networks that exploit hybridisation reactions carried out by small RNAs that are both targets of and triggers for other sRNAs.

4. Safe-by-design: from safety to responsibilityNanoEthics

The safety of technology depends on the behaviour of the user but by designing out the user, opportunities may be missed. Ways to decide how to share and distribute responsibility for safety through design are presented.

5. A symbiotic-like biologically-driven regenerating fabric, Nature Scientific Reports

Fabric is integrated with a bacterial biofilm in order to form a symbiotic relationship in which the biofilm is provided with structure and support, and the fabric with regenerative properties.

6. Performance of objective functions and optimisation procedures for parameter estimation in system biology models, NPJ Systems Biology and Applications

An investigation into how the number of unknown parameters affects the convergence of three frequently used optimisation algorithms and four objective functions in system and synthetic biology.

7. Computational re-design of synthetic genetic oscillators for independent amplitude and frequency modulation, bioRxiv

How recent advances in tuneable synthetic degradation can be used to decouple the frequency and amplitude modulation in synthetic genetic oscillators, illustrated through computational re-designs.

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