Posted 8th January 2018 by Jane Williams
Antibody-drug conjugates (ADCs) combine the high specificity of a monoclonal antibody (mAb) for a target antigen with the highly potent cytotoxic activity of small-molecule drugs. Although the concept behind ADCs is relatively simple, the successful design and development of ADCs is a complex task. Similar to other biotherapeutics, the understanding of Pharmacokinetics (PK), Pharmacodynamics (PD), and Absorption, Distribution, Metabolism, and Excretion (ADME) properties of ADCs is critical for their successful development.
Posted 23rd December 2016 by Jane Williams
My research activity focuses on the exploration of new drug delivery technology (categorised into polymer complex/conjugates, nanomedicine, and various types of drug delivery formulations) and the application of validated drug delivery technology to NCE candidates in early/exploratory research stages.