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Tag: microfluidics

Dynamic Microenvironments: Finding the right cancer therapy

With so many promising cancer therapies emerging from research labs, a key challenge for biomedical researchers is to develop tools that accurately predict treatment efficacy against a patient’s specific cancer, thereby avoiding subjecting the patient to a trial and error process to find the best drug.

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Molecular Diagnostics for the Point of Care

Here, we use the term molecular diagnostics to refer to tests that detect the presence of specific nucleic acids in a clinical specimen such as blood, urine, faeces, saliva, and tissue. These nucleic acids serve, among other things, as biomarkers for the presence of infection-causing pathogens (e.g., DNA and/or RNA from bacteria, virus, and/or parasites); diseases such as cancer (characterised by mutant alleles), and genetic abnormalities.

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Microfluidic Droplets on Demand

Active droplet generation in microfluidics is of high interest for a wide range of applications such as single cell analysis, DNA sequencing and nanoparticle synthesis to name a few.

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The Microfluidic Match – A Sports Analogy

For sports fans, the “sweet spot” often means the perfect point of contact between two moving objects, be it a baseball bat trying to hit a wicked curve ball or a footballer (soccer player) smacking a well-timed bicycle kick into the corner of the net. To score a goal for microfluidic researchers, it often involves a perfect “match” between a developing novel technology and a groundbreaking application or scientific discovery.

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Working at GlaxoSmithKline: A process engineer’s perspective

David Lai applies microfluidic droplets for pharmaceutical secondary manufacturing with GSK where he splits his responsibilities between the departments of Advanced Manufacturing Technologies, Product and Process Engineering, and Drug Design and Selection. We spoke to him about his work.

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Shaped paper pumps for microfluidic devices

Glenn Walker, Associate Professor at North Carolina State University, is working with colleagues in the Department of Biomedical Engineering to develop low-cost, disposable pumps that can power a wide range of microfluidic devices. The pumps are made by laminating shaped pieces of commercially available filter paper, so they are inexpensive and easily fabricated by just about anyone.

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An open letter from George Whitesides

Dear Colleagues,

In the past decade, microfluidics has emerged as a distinct new field with the potential to influence subjects from chemical synthesis and biological analysis to optics and information technology.

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Applications of microfluidics in the real world

We examine some of the newest applications of microfluidics, including for environmental and clinical detection using paper-based devices, for detection of cancer markers using droplet digital microfluidics, and for assisted-reproductive technology.

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