Posted 21st October 2020 by Joshua Sewell
Constant production of proteins in living cells is subject to strict quality and concentration control. The ubiquitin-protease system (UPS) is one of the systems responsible for degrading misfolded and damaged proteins. Also, short-lived regulatory proteins that control many critical cellular processes, including cell cycle progression, cell proliferation and differentiation, cell signalling and transcription are degraded by UPS.1
Posted 20th May 2019 by Joshua Sewell
We are building the solutions that will revolutionise healthcare in the future: solutions that will transform the trust relationship between the industry and patients, and the whole dynamic of healthcare. As co-founder of 23 Consulting, I am involved in supporting health organisations with their blockchain projects.
Posted 26th April 2019 by Joshua Sewell
Alongside my primary role as a Project Manager, I have since 2016 been the Roche lead for the IMI industry collaboration called EHR4CR. EHR4CR is a group of roughly 10 pharma companies, universities, and SMEs working together to leverage the great wealth of information from hospitals in order to support our clinical trials and promote innovative research. It was a 7-year $16 million project.
Posted 15th April 2019 by Joshua Sewell
Merck, Sharp & Dohme operates a hub model with IT hubs in the US, Czech Republic, and Singapore.
All operations and important functions of IT are distributed within those three hubs. It ensures not only that we follow the standard model but also ensures the regional presence and cooperation with the sites in any region.
Posted 16th February 2018 by Jane Williams
Recent microbiome research has demonstrated the important role that these communities of microorganisms play on human homeostasis. The gut microbiome is being thoroughly studied, and other microbiomes are now becoming the focus of greater attention, as well as other organs of the host, due to the concept of ‘axes,’ such as the gut-brain axis, gut-lung axis, gut-liver axis.