Harvesting the power of the cell’s own protein degradation mechanisms in drug discovery
Posted 21st October 2020 by Joshua Sewell
Constant production of proteins in living cells is subject to strict quality and concentration control. The ubiquitin-protease system (UPS) is one of the systems responsible for degrading misfolded and damaged proteins. Also, short-lived regulatory proteins that control many critical cellular processes, including cell cycle progression, cell proliferation and differentiation, cell signalling and transcription are degraded by UPS.1
PROTAC drug discovery – prior preparation and planning
Posted 1st July 2020 by Liv Sewell
“By failing to prepare, you are preparing to fail” so said Benjamin Franklin, and as a veteran of early stage drug discovery you can bet that I, like you, have seen my fair share of successes but also more failures than I’d like.
Slides from the 4th Medicinal Chemistry & Protein Degradation Summit
Posted 26th November 2019 by Joshua Sewell
The 4th Medicinal Chemistry & Protein Degradation Summit provided two days of fascinating topics and case studies about AI-assisted lead optimisation, DNA encoded libraries and the use of data and informatics in drug-discovery. We have made the following presentation slides available from Greg Makara, Paul Colbon and Yugal Sharma.
Optimising Targeted Protein Degradation
Posted 26th March 2018 by Jane Williams
02MedChemNet and Future Medicinal Chemistry editors Jasmine Harris and Ben Walden interviewed George Burslem from Yale University at the Global Medicinal Chemistry and GPCR Summit.